Rajita Sinha

Prazosin-Related Reductions in Daily Craving Mediate Treatment-Related Daily Alcohol Use Outcomes in Alcohol Use Disorder

Stephanie Wemm, Rachel Hart, Gretchen Hermes, Zachary M. Harvanek et autres

Background Prazosin has been shown to reduce drinking, particularly in individuals with alcohol withdrawal symptoms, possibly due to reducing craving as shown in experimental studies. However, it is unclear whether prazosin decreases daily changes in alcohol craving and if such changes drive …

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Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue–provoked pain responses in individuals with alcohol use disorder.

Riley Quinlan, Huaze Gao, Rajita Sinha, Verica Milivojevic

= .213). PREG dose specifically reduced stress-provoked pain responses and affected concurrent pain and craving and anxiety associations, warranting further examination of PREG effects on pain and alcohol use outcomes in AUD. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

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Perceived Social Support Moderates the Response to Stress and Alcohol Cues During Early Abstinence From Alcohol

Samantha J. Goldstein, Rajita Sinha, Helen C. Fox

Background: Alcohol addiction is associated with maladaptive stress responses that heighten craving and relapse risk during early abstinence. While perceived social support (PSS) is theorized to act as a stress buffer, its influence on acute stress responses during early abstinence remains poorly …

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Alterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study

Zachary M. Harvanek, Verica Milivojevic, Rachel Hart, Rajita Sinha

BACKGROUND: Alcohol use disorders (AUD) and obesity (OB) are highly prevalent and often comorbid. Recent evidence suggests potential mechanistic overlap that may impact treatments such as Glucagon-like Peptide 1 receptor agonists (GLP1-RAs) for AUD. While alcohol intake can affect blood glucose control, …

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Neighborhood Deprivation Is Associated with Accelerated Epigenetic Aging Via Greater Individual Adversity

Alija S Koirala, Justin R Shields, Anjali S Vijan, Stephanie Wemm et autres

Importance: Adverse neighborhood conditions can lead to poorer health outcomes, potentially through accelerated biological aging. However, whether these relationships are explained by individual- or neighborhood-level factors remains unclear. Objective: To examine the association between neighborhood deprivation, measured by the Area Deprivation Index …

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326. Lifetime Adversity Partially Mediates Relationships Between Neighborhood Deprivation and Biological Aging

Alija Koirala, Justin Shields, Anjali Vijan, Stephanie Wemm et autres

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579. Neural Signatures of Stress Dysregulation in Chronic Pain: Preliminary Findings

Milena Radoman, Cheryl Lacadie, Rajita Sinha

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196. Social Connection Partially Mediates the Relationship Between Chronic Stress and Health in Adults

Anjali Vijan, Justin Shields, Alija Koirala, Rajita Sinha et autres

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574. Neighborhood Obesity Prevalence Interacts With Personal BMI to Predict Stress Outcomes in Community Adults

Justin Shields, Alija Koirala, Anjali Vijan, Ania Jastreboff et autres

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205. Lifetime Adversity is Associated With DNA Methylation at Obesity-Associated Genes

Adaiah Stevens, Ania Jastreboff, Ke Xu, Rajita Sinha et autres

7. The Neurosteroid Pregnenolone Effects on Stress- And Cue- Provoked Alcohol Craving Associations With Drinking Outcomes in Individuals With Alcohol Use Disorder

Elcin Sakmar, Stephanie Wemm, Nia Fogelman, Rajita Sinha et autres

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381. Effects of Daily 8-WEEK Exogenous Pregnenolone Treatment on Downstream Metabolite Levels in Individuals With Alcohol Use Disorder

Verica Milivojevic, Nia Fogelman, Rajita Sinha

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