Aysegul Atasoy‐Zeybek

The intersection of aging and estrogen in osteoarthritis

Aysegul Atasoy‐Zeybek, Kelly K. Showel, Christopher V. Nagelli, Jennifer J. Westendorf et autres

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age and sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in OA risk after menopause suggests estrogen …

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Contributors

Paul W. Ackermann, Emmanuela Adjei‐Sowah, Aisha Ahmed, Ana F. Almeida et autres

Gene transfer to tendon

R. S. Sherwin, E.B. McGlinch, Aysegul Atasoy‐Zeybek, Carlos Julio Peniche Silva et autres

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Transcriptomic Changes During the Replicative Senescence of Human Articular Chondrocytes

Aysegul Atasoy‐Zeybek, Gresin P. Hawse, Christopher V. Nagelli, Consuelo M. López de Padilla et autres

Aging is a major risk factor for osteoarthritis (OA), but the specific mechanisms connecting aging and OA remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo replicative senescence in vitro, offering a model to study aging-related changes under controlled …

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Transcriptomic changes during the replicative senescence of human articular chondrocytes

Aysegul Atasoy‐Zeybek, Gresin P. Hawse, Christopher V. Nagelli, Consuelo Lopez De Padilla et autres

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AAV-mediated, in vivo gene delivery to the rotator cuff

R. S. Sherwin, E.B. McGlinch, Barry Ma, CM Lopez De Padilla et autres

European Cells & Materials Journal - Open and Free Access - The Official Research Journal of AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)

Transcriptomic changes during the replicative senescence of human articular chondrocytes

Aysegul Atasoy‐Zeybek, Gresin P. Hawse, Christopher V. Nagelli, Consuelo Lopez De Padilla et autres

Abstract Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability worldwide. Aging is a major risk factor for OA, but the specific mechanisms underlying this connection remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo …

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Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2

Aysegul Atasoy‐Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart‐Avramoglou et autres

Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclinical models of bone healing using gene …

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Segmental defect healing in the presence or absence of recombinant human BMP2: Novel insights from a rat model

Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch et autres

This study defined and compared the course of native, impaired and growth factor-stimulated bone regeneration in a rat femoral defect model. A mid-diaphyseal defect with rigid internal fixation was surgically created in the right femur of male Fischer rats and serially analyzed …

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IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification

Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch et autres

An estimated 100,000 patients each year in the United States suffer severe disability from bone defects that fail to heal, a condition where bone-regenerative therapies could provide substantial clinical benefits. Although recombinant human bone morphogenetic protein-2 (rhBMP2) is an osteogenic growth factor …

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Gene therapy for bone healing: lessons learned and new approaches

Rodolfo E. De la Vega, Aysegul Atasoy‐Zeybek, Joseph A. Panos, Martijn van Griensven et autres

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Paracrine effects of living human bone particles on the osteogenic differentiation of mesenchymal stem cells

Aysegul Atasoy‐Zeybek, Alan Ivković, Tahsin Beyzadeoğlu, Ana Oña et autres

Bone autografting remains the clinical model of choice for resolving problematic fractures. The precise mechanisms through which the autograft promotes bone healing are unknown. The present study examined the hypothesis that cells within the autograft secrete osteogenic factors promoting the differentiation of …

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