Suguru Hayase

Loss of NKX2-1 predisposes thyroid to neoplasm development through regulation of oxidative stress

Yo-Taro Shirai, Jerrold Michael Ward, Yoshinori Takizawa, Huaitian Liu et autres

Abstract Many factors including ionizing radiation and iodine deficiency are known to increase thyroid carcinogenesis risk. Our dataset analysis of The Cancer Genome Atlas (TCGA) showed that lower mRNA expression of NK2 homeobox 1 ( NKX2-1 ) transcription factor, a master regulator …

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Potential utility of the Tumguide® LED Light Source for safe and accurate gastric tube placement during laparoscopic gastrectomy

Yuto Rai, Suguru Hayase, Chiaki Nemoto, Satoki Inoue

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Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer

Kosaku Mimura, Takashi Ogata, Roy S, Hassen Kared et autres

BACKGROUND: Tumor-associated antigen (TAA)-specific CD8(+) T cells are essential for nivolumab therapy, and irradiation has been reported to have the potential to generate and activate TAA-specific CD8(+) T cells. However, mechanistic insights of T-cell response during combinatorial immunotherapy using radiotherapy and nivolumab …

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Immunological Responses Associated With Neoadjuvant Therapy in the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma

Yuka Takehara, Tomoaki Tamaki, Kosaku Mimura, Katsuharu Saito et autres

BACKGROUND/AIM: Development of multidisciplinary therapies including immune checkpoint inhibitors for esophageal squamous cell carcinoma (ESCC) requires a clear understanding of immunological responses induced by chemotherapy with/without radiotherapy in the tumor microenvironment. PATIENTS AND METHODS: This is a retrospective analysis of paired pretreatment …

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Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Kosaku Mimura, Takashi Ogata, Yuya Yoshimoto, Daisaku Yoshida et autres

BACKGROUND: Although immune checkpoint inhibitors (ICI) targeting for PD-1 axis is a promising approach for advanced gastric cancer (GC) patients, the response rate is still limited. Induction of synergistic effect of irradiation with ICI targeting for the PD-1 axis can be an …

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Supplementary Table S1 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

Univariate and multivariate analyses of risk factors for OS and RFS after NAC in patients with ESCC

Supplementary Figures 1-6 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

S1. Measurement of the number of CD163+ cells and their expression intensities in ESCC specimens. S2. IHC staining of CSF-1, IL-34, E-cadherin, and vimentin in ESCC specimens. S3. Correlation between mRNA expression of CD163 and CSF-1 in patients with ESCC who underwent …

Supplementary Figures 1-6 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

S1. Measurement of the number of CD163+ cells and their expression intensities in ESCC specimens. S2. IHC staining of CSF-1, IL-34, E-cadherin, and vimentin in ESCC specimens. S3. Correlation between mRNA expression of CD163 and CSF-1 in patients with ESCC who underwent …

Supplementary Table S1 from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

Univariate and multivariate analyses of risk factors for OS and RFS after NAC in patients with ESCC

Data from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

Abstract The tumor microenvironment (TME) plays a key role in the efficacy of neoadjuvant chemotherapy (NAC) in solid tumors including esophageal squamous cell carcinoma (ESCC). However, the TME profile of ESCC treated with NAC is not fully understood. In this study, we …

Data from Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma

Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min et autres

Abstract The tumor microenvironment (TME) plays a key role in the efficacy of neoadjuvant chemotherapy (NAC) in solid tumors including esophageal squamous cell carcinoma (ESCC). However, the TME profile of ESCC treated with NAC is not fully understood. In this study, we …

Systemic inflammation score as a preoperative prognostic factor for patients with pT2–T4 resectable gastric cancer: a retrospective study

Takuro Matsumoto, Shinji Ohki, Akinao Kaneta, Akira Matsuishi et autres

BACKGROUND: Systemic inflammation has been reported to be associated with cancer progression and metastasis. Systemic inflammation score (SIS), calculated from preoperative serum albumin level and lymphocyte-to-monocyte ratio, has been shown to be a novel prognostic factor for several types of tumors. This …

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