Paulyna Magaña

AlphaFold Database expands to proteome-scale quaternary structures

Jennifer R. Fleming, Yewon Han, Maxim Tsenkov, Niccolo Venanzi et autres

kr, gb, us, ru (code pays fourni par la source)

Towards globally equitable bioinformatics adoption

Paulyna Magaña, Piraveen Gopalasingam, Jennifer R. Fleming, Oleg Kovalevskiy et autres

Advances in artificial intelligence (AI)-driven bioinformatics promise democratized discovery, yet major inequities persist. Equitable adoption of bioinformatics tools will require sustained investment in infrastructure, training, institutions, and global communities, not just access.

gb, Ouganda, bd, mx, in, Mali, Afrique du Sud, cl, Mozambique, br, cr, Ghana, Kenya, Cameroun, Tunisie, ar, lk (code pays fourni par la source)

AlphaFold Database expands to proteome-scale quaternary structures

Yewon Han, Maxim I. Tsenkov, Niccolo A. E. Venanzi, Sooyoung Cha et autres

Abstract Protein function is governed by molecular interactions, yet structural coverage of these interactions remains sparse. The AlphaFold Protein Structure Database (AFDB) transformed access to accurate monomeric protein structures at scale. Here, we expand the AFDB to quaternary structures by predicting 31M …

kr, gb, us (code pays fourni par la source)

The AlphaFold educational summit provides insights into advancing global equity in computational structural biology

Paulyna Magaña, Piraveen Gopalasingam, Jennifer Fleming, Oleg V. Kovalevskiy et autres

AlphaFold is a state-of-the-art protein structure prediction resource that offers immense potential for accelerating scientific discovery. Realising this potential, however, requires equitable access to technology, resources and expertise. To address this need, the AlphaFold Education Summit, held at the Wellcome Genome Campus …

gb, us, Ouganda, in, bd, mx, nl, Mali, Afrique du Sud, Mozambique, br, cl, cr, bo, Tunisie, np, es, lk, ar (code pays fourni par la source)

Determination of interaction properties between PEGylated proteins and a modified resin by Isothermal Titration Calorimetry (ITC) and FTIR

Paulyna Magaña

PEGylated proteins are an increasing important class of therapeutic drugs due to their improved pharmacokinetic characteristics and solubility over their corresponding native forms. PEGylation is the covalent attachment of one or more polyethylene glycol (PEG) molecules to a protein. Despite the many …