Angela M. Huang

26-A-8609-ACC ENHANCING THE DIAGNOSTIC ACCURACY OF TRANSTHYRETIN AMYLOID CARDIOMYOPATHY AND ADDRESSING CARE DISPARITIES IN RURAL CENTRAL FLORIDA - UNVEILING CARDIAC AMYLOIDOSIS IN AN UNDERSERVED COMMUNITY

Yelena Pleshkova, Jordan Casola, Muhammad Sohaib Asghar, Muhammad Ahmad Majid et autres

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26-A-11699-ACC ACCELERATING DIAGNOSIS OF TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN RURAL PRACTICE-OUTCOMES OF A MODIFIED PROTOCOL IMPLEMENTATION QUALITY IMPROVEMENT INITIATIVE

Yelena Pleshkova, Anika Bhandare, Jordan Casola, Jatin Kumar Passi et autres

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26-CCC-8375-ACC ENHANCING THE DIAGNOSTIC ACCURACY OF TRANSTHYRETIN AMYLOID CARDIOMYOPATHY AND ADDRESSING CARE DISPARITIES IN RURAL CENTRAL FLORIDA: UNVEILING CARDIAC AMYLOIDOSIS IN AN UNDERSERVED COMMUNITY

Yelena Pleshkova, Jordan Casola, Muhammad Sohaib Asghar, Deepti Bhandare et autres

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26-A-17799-ACC NATIONAL TRENDS IN ALL-CAUSE READMISSIONS, IN-HOSPITAL MORTALITY, AND HEALTHCARE UTILIZATION AMONG AMYLOIDOSIS HOSPITALIZATIONS: INSIGHTS FROM THE NATIONAL READMISSION DATABASE (2016-2022)

Rishabh Tandon, Muhammad Sohaib Asghar, Ahmad Barbour, Jatin Kumar Passi et autres

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TCR-dependent CD8+ T cell responses drive atherosclerotic plaque instability 2443

Jonathan Edward Noonan, Nicholas C. Borcherding, Nicholas A. Gherardin, Lisa M. Domke et autres

Abstract Description Atherosclerosis is a chronic inflammatory condition of the arterial vasculature. The rupture of atherosclerotic plaques, leading to myocardial infarctions, underpins most cardiovascular disease-related morbidity and mortality. However, the specific immune pathways that drive atherosclerotic plaque destabilization and rupture remain poorly …

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CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion

Jonathan Edward Noonan, Shania A Prijaya, Laura A. Bienvenu, Nalin H. Dayawansa et autres

AIMS: T cells drive adverse cardiac inflammation and ischemia-reperfusion injury following myocardial infarction (MI). Here, we aimed to test the extent to which T cell inhibition protected cardiac function following MI in mice. METHODS AND RESULTS: Cardiac ischemia-reperfusion injury (CIRI), mimicking MI …

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CTLA-4-Ig Therapy Preserves Cardiac Function Following Myocardial Infarction With Reperfusion

Shania A Prijaya, Jonathan Edward Noonan, Laura A. Bienvenu, Nalin H. Dayawansa et autres

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Visceral adipose tissue demonstrates a stronger association with venous thromboembolism than body mass index

Ruidong Xiang, Angela M. Huang, Hannah Stevens, Manika Singh et autres

BACKGROUND: Increased body mass index is associated with an increased risk of venous thrombosis. However, recent data have highlighted that visceral adipose tissue (VAT) volume may be a better marker of cardiometabolic risk. OBJECTIVES: This study aimed to investigate the relationship between …

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Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis

Yiyao Catherine Chen, Naveen Eugene Louis, Angela M. Huang, Allan Sun et autres

ABSTRACT: Rare thrombotic events associated with ChAdOx1 nCoV-19 (ChAdOx1) vaccination have raised concerns; however, the underlying mechanisms remain elusive. Here, we report a novel biophysical mechanism by which ChAdOx1 directly interacts with platelets under arterial shear conditions, potentially contributing to postvaccination arterial …

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Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation

Johannes Zeller, Julia Loseff-Silver, Khashayar Khoshmanesh, Sara Baratchi et autres

BACKGROUND: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity. Pathophysiological shear rates as observed in aortic valve stenosis (AS) …

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Piezo1 expression in neutrophils regulates shear-induced NETosis

Sara Baratchi, Habiba Danish, Chanly Chheang, Ying Zhou et autres

Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood cells to attach to. In circulation, neutrophils are constantly exposed …

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Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients

Emily Eribes, Cassandra D. Votruba, Tyler Tinkham, Angela M. Huang et autres

Tixagevimab/cilgavimab (tix/cil) received emergency use authorization in December 2021 for pre-exposure prophylaxis against COVID-19 in moderately to severely immunocompromised patients. Our study aimed to describe the incidence of COVID-19 infection and assess the immunologic risks associated with tix/cil in kidney, pancreas, liver, …

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