Paul McGillan

Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

Paul McGillan, Neil G. Berry, Gemma L. Nixon, Suet C. Leung et autres

High Resolution Image Download MS PowerPoint Slide Anti- Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti- Wolbachia activity. This paper focuses on the exploration of the …

gb (code pays fourni par la source)

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong et autres

Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of AstraZeneca's 1.3 million in-house compound library and identify 5 novel chemotypes with faster …

gb, se, us (code pays fourni par la source)

Development of Small-Molecule Anti-Wolbachia Agents for the Treatment of Filariasis

Paul McGillan

Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials

Paul M. O' Neill, Sunil Sabbani, Gemma L. Nixon, Matthew Schnaderbeck et autres

gb, us, Ghana (code pays fourni par la source)