Andrei Miclea

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena et autres

Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the concentrations …

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Novel Serum Biomarker Associations with 7 Tesla MRI-defined Cortical Lesions, Leptomeningeal Enhancement, and Deep Gray Matter Volume in Early Multiple Sclerosis (P9-1.017)

Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena et autres

Because of the persisting unmet need to identify biomarkers with prognostic clinical utility in MS, the objective of the present study is to characterize the relationship between 7 Tesla MRI-defined measures of disease severity (gray matter demyelinating lesions, brain atrophy, and meningeal …

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Evaluation of diagnostic criteria and red flags of myelin oligodendrocyte glycoprotein encephalomyelitis in a clinical routine cohort

Krenar Veselaj, Nicole Kamber, Myriam Briner, Christoph Friedli et autres

AIMS: Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been proposed to define "MOG encephalomyelitis" (MOG-EM), with published diagnostic and "red flag" criteria. We aimed to evaluate these criteria in a routine clinical setting. METHODS: We retrospectively analyzed patients with borderline/positive MOG-IgG and applied …

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A Brief Review of the Effects of Vitamin D on Multiple Sclerosis

Andrei Miclea, Maud Bagnoud, Andrew Chan, Robert Hoepner

Multiple sclerosis (MS) is characterized as an autoimmune disease affecting the central nervous system. It is one of the most common neurological disorders in young adults. Over the past decades, increasing evidence suggested that hypovitaminosis D is a contributing factor to the …

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Dimethyl fumarate vs fingolimod following different pretreatments

Lara Diem, Ariadne Daponte, Oliver Findling, Andrei Miclea et autres

Objective Despite frequent use of fingolimod (FTY) and dimethyl fumarate (DMF), studies comparing clinical efficacy and withdrawal rates of DMF and FTY concerning different pretreatment situations are rare. The aim of our study was to compare relapse occurrence and withdrawal rates of …

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IMPLEMENTATION OF CROSS-ZONAL INTRADAY CAPACITY PRICING

Andrei Miclea, Ionut JDERU

Rezumat: Lucrarea de fata descrie modul in care preturile capacitatii intrazilnice interzonale vor fi implementate pe baza unei metodologii unice la nivel european. Sunt prezentate optiunile identificate si solutia adoptata pentru implementare, precum si stadiul actual si perspectivele al proiectului.

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Prediction of conversion to multiple sclerosis using the 2017 McDonald and 2016 MAGNIMS criteria in patients with clinically isolated syndrome: a retrospective single-centre study

Andrei Miclea, Anke Salmen, Roland Wiest, Greta Zoehner et autres

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Time course of lymphocyte repopulation after dimethyl fumarate-induced grade 3 lymphopenia: contribution of patient age

Myriam Briner, Maud Bagnoud, Andrei Miclea, Christoph Friedli et autres

BACKGROUND: Dimethyl fumarate (DMF) is licensed for treatment of relapsing-remitting multiple sclerosis (RRMS). DMF can induce lymphopenia, which is assumed to increase the risk for opportunistic infections like progressive multifocal leukoencephalopathy. Our goal for this work was to estimate the frequency of …

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Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course

Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber et autres

Background: In multiple sclerosis (MS), the frequency of hypogammaglobulinemia is unknown. We aimed to evaluate the frequency of reduced immunoglobulin (Ig) concentrations and its association with immunotherapy and disease course in two independent MS cohorts. Methods: In our retrospective cross-sectional study, MS …

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Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis

Nic Skorupka, Andrei Miclea, Katarzyna Aleksandra Jalowiec, Christoph Bocksrucker et autres

Introduction: In acute inflammatory optic neuritis (ON) as a typical onset of multiple sclerosis (MS), only few studies have investigated plasma exchange (PLEX) as a sequential treatment after insufficient response to high-dose intravenous glucocorticosteroids. Therefore, we aimed to investigate treatment outcome on …

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Age‐dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross‐sectional study

Andrei Miclea, Anke Salmen, Greta Zoehner, Lara Diem et autres

INTRODUCTION: Multiple sclerosis (MS) is an autoimmune disease of the CNS, which predominantly affects women. Studies investigating the sex distribution in MS are sparse. We aim to analyze the female-to-male ratio (F/M ratio) in different MS phenotypes in association with age at …

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Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod

Maria‐Eleftheria Evangelopoulos, Andrei Miclea, Lisa Schrewe, Myriam Briner et autres

Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod310030_175561/1).Chan A has received personal compensation for activities with

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