Yufang F. Xu

Microfluidic-Directed Self-Assembly of dsRNA-Fungicide Nanocomplexes toward Synergistically Enhanced Disease Control

Ting Li, Shuqin Wu, Shuning Chen, Tengyu Lei et autres

Abstract Botrytis cinerea (B. cinerea) causes severe agricultural losses. RNA interference (RNAi) offers precise control but is limited by dsRNA instability and inefficient delivery. Here, dsRNA targeting an ergosterol biosynthesis gene (dsERG) and berberine (BBR) self-assembled into carrier-free nanocomplexes (NCsdsERG-BBR) via microfluidics. …

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End-to-End Continuous Synthesis and Crystallization of Clopidogrel Bisulfate: Process Intensification and Solid-Form Control

Feiyan Zhan, Mengran Du, Wenbo Jiang, Yan Chen et autres

Abstract The conventional batch manufacturing of clopidogrel bisulfate is constrained by low process efficiency and poor control over pharmaceutically preferred yet metastable Form I. Herein, we report an end-to-end continuous manufacturing process that combines multistep synthesis with a nucleation–growth decoupled crystallization strategy …

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Design and Structural Optimization of Orally Bioavailable RSK4 Inhibitors for the Treatment of Esophageal Squamous Cell Carcinoma

Limin Leng, Shuai He, Manzhan Zhang, Yanru Yang et autres

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with limited targeted treatment options. Ribosomal S6 protein kinase 4 (RSK4) is a potential therapeutic target, yet few potent and specific inhibitors have been reported. In this study, we designed and synthesized …

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A mobile tool for static standing posture assessment using accurate 3D body reconstruction

Qingguang Chen, Yingying Pan, Xinghao Zhang, Jiajin Liu et autres

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Modular continuous flow synthesis of zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing

Yan Chen, Rongkun Jiang, Fang Zhao, Yufang F. Xu et autres

The two-stage integrated continuous flow synthesis of zidovudine ( AZT ) was accomplished, addressing the core challenges in converting zidovudine synthesis from batch to fully flow, particularly concerning solvent and reagent compatibility.

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Author response for "Modular continuous flow synthesis of Zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing"

Yan Chen, Rongkun Jiang, Fang Zhao, Yufang F. Xu et autres

Author response for "Dual-site Recognition Leads to a Ratiometric Fluorescent Probe for Norepinephrine: Quantitative Detection and Visualization for in-depth Understanding of Hypertension"

Fengzhi Wang, Jiawen Wang, Weiping Zhu, Yangyang Yang et autres

Direct Ser797 Interacted Pteridine-7(8 H )-one Derivatives as Highly Selective and Orally Available EGFRL858R/T790M/C797S Inhibitors

Wenzhe Jiang, Yongning He, Yongxiang Wang, Hongguang Du et autres

Abstract The EGFRC797S mutation is the main mechanism of acquired resistance to Osimertinib in NSCLC. There is an urgent need for small-molecule inhibitors to overcome Osimertinib-resistance. In this article, we developed a series of pteridin-7(8H)-one-derived inhibitors of EGFRL858R/T790M/C797S (EGFRLR/TM/CS) integrating direct interactions …

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Bioequivalence Study of Palbociclib Tablets in Healthy Volunteers

Yiting Hu, Na Zhao, Haojing Song, Jian Zhang et autres

Objective: Bioequivalence of palbociclib tablets was evaluated in healthy volunteers under fasting and fed conditions in this study. Methods: This bioequivalence trial, which randomized subjects to receive palbociclib under fed or fasted conditions, generated these results. High-performance liquid chromatography-mass spectrometry (HPLC-MS) was …

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Microfluidic Manipulation Enabling Controllable and Eco-Friendly Lambda-Cyhalothrin Nanopesticides for Highly Efficient Pest Control

Shuqin Wu, Jinshan Xie, Yufang F. Xu, Xuhong H. Qian et autres

Nanopesticides have emerged as a highly promising approach for plant protection. Importantly, their preparation process plays a crucial role in determining their particle characteristics and impacting crop protection efficacy. Unfortunately, current nanopesticides exhibit predominantly large size distributions and uncontrollable morphologies, leading to …

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Inactivation of RhoA for Hypertension Treatment Through the TRPV4–RhoA–RhoGDI1 Axis

Zhen Yuan, Na Hee Yu, Qian Jiao, Honglei Zhou et autres

BACKGROUND: The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, …

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Construction of naphthalimide-based near-infrared hemicyanine fluorophore and its application for in vivo bioimaging

Zhixiao Xiong, Yucheng Wu, Shanni Qiu, Yufang F. Xu et autres

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