Heather A. Hundley

ADARs mediate distinct RNA editing activity and gene regulation in the Caenorhabditis elegans germline

Emily A. Erdmann, Leanne H Kelley, Heather A. Hundley

Tissues rely on unique landscapes of gene regulation to allow the organism to correctly develop, function, and respond to changes. One component of these gene regulatory networks is RNA Binding Proteins (RBPs) which bind and modify RNA molecules leading to changes in …

us (code pays fourni par la source)

A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR

Yang Yi, Yanqiang Li, Rui Wang, Xufen Yu et autres

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a widespread modification in metazoans. Cumulative evidence has revealed the altered A-to-I editing profiles in cancers, but the underlying mechanism remains unclear. Here, we discover the well-known histone lysine …

us, ca (code pays fourni par la source)

ADARs mediate distinct RNA editing activity and gene regulation in the Caenorhabditis elegans germline

Emily A. Erdmann, Heather A. Hundley

Abstract Tissues rely on unique landscapes of gene regulation to allow the organism to correctly develop, function, and respond to changes. One component of these gene regulatory networks is RNA Binding Proteins (RBPs) which bind and modify RNA molecules leading to changes …

us (code pays fourni par la source)

eIF4E assembly into C. elegans germ granules is essential for its repressive function

Carmen Herrera Sandoval, Christopher Borchers, Boyoon Yang, Heather A. Hundley et autres

Abstract Metazoan germ cells form intracellular germ granules, cytoplasmic RNA-protein condensates that contain a variety of RNAs and proteins essential for germline identity, maintenance, and fertility. P granules are a type of C. elegans germ granule proposed to be sites of mRNA …

us (code pays fourni par la source)

RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA

Nabeel S. Ganem, Dean Light, Roni Haas, Boaz Goldstein et autres

Abstract The ability of an organism to identify self and foreign RNA is central to eliciting an immune response in times of need while avoiding autoimmunity. As viral pathogens typically employ double-stranded RNA (dsRNA), host identification, modulation, and response to dsRNA is …

il, us (code pays fourni par la source)

The kinase GSK-3 alters the RNA-binding protein landscape of lipid metabolism transcripts leading to altered expression in the C. elegans nervous system

Ananya Mahapatra, Heather A. Hundley

Tissue-specific regulation of gene expression is essential for multicellular organisms, and RNA-binding proteins play central roles in these molecular processes. To determine how the Caenorhabditis elegans RNA-binding protein, ADR-1, regulates tissue-specific gene expression, we profiled the RNA-binding targets of ADR-1 in neural …

us (code pays fourni par la source)

Abstract 2002 ADR-2 regulates the germline transcriptome and affects fertility and oocyte fate

Emily A. Erdmann, Heather A. Hundley

RNA-binding proteins (RBPs) play essential roles in coordinating proper gene expression and development in all organisms. Adenosine DeAminases that act on RNA (ADARs) are a class of RBPs that regulate cellular processes at the RNA level by binding to double-stranded RNA (dsRNA) …

us (code pays fourni par la source)

Abstract 2524 The kinase GSK-3 regulates the RNA binding protein landscape in the nervous system to control survival to hypoxia

Heather A. Hundley, Ananya Mahapatra

optimized mechanical injury model on C. elegans.This will lead us to further design our experiments for deeper investigation of the neurodegenerative mechanisms post mechanical injury.

us (code pays fourni par la source)

A probe-based capture enrichment method for detection of A-to-I editing in low abundance transcripts

Emma Lamb, Boyoon Yang, Heather A. Hundley

us (code pays fourni par la source)

ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans

Emily A. Erdmann, Melanie Forbes, Margaret Becker, Sarina Perez et autres

RNA-binding proteins (RBPs) play essential roles in coordinating germline gene expression and development in all organisms. Here, we report that loss of ADR-2, a member of the adenosine deaminase acting on RNA family of RBPs and the sole adenosine-to-inosine RNA-editing enzyme in …

us (code pays fourni par la source)

ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection

Berta Eliad, N Schneider, Orna Ben-Naim Zgayer, Yarden Amichan et autres

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a prevalent and conserved RNA modification. While A-to-I RNA editing is essential in mammals, in Caenorhabditis elegans, it is not, making them invaluable for RNA editing research. In C. elegans, ADR-2 is the …

il, us (code pays fourni par la source)

ADARs regulate cuticle collagen expression and promote survival to pathogen infection

Alfa Dhakal, Chinnu Salim, Mary Skelly, Yarden Amichan et autres

BACKGROUND: In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that act on RNA (ADAR) family of RNA-binding proteins …

us, il (code pays fourni par la source)