Alexandros C. Makis

Endothelial Dysfunction in β-Thalassemia: Mechanisms, Biomarkers, Vascular Imaging and Therapeutic Perspectives

Alexandros C. Makis, Ioanna Saougou, Antonios P. Vlahos

Background/Objectives: Endothelial dysfunction is increasingly recognized as a key contributor to vascular complications in β-thalassemia but remains insufficiently integrated into clinical assessment and therapeutic trial design. This review summarizes current evidence on the mechanisms, biomarkers, vascular imaging findings, and therapeutic perspectives of …

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Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

Alexandros C. Makis, Ioanna Saougou, Eleftheria ChR. Hatzimichael

Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme …

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Artificial Intelligence–Enabled Approaches to Enhance Maternal Vaccine Uptake: Implementation Opportunities, Challenges, and Ethical Implications

Nefeli Prompona, Marianna Efstratiadou, Aikaterini I. Nikolaou, Alexandros C. Makis et autres

Maternal vaccination is an important component of antenatal care, yet uptake of influenza, pertussis, and more recently introduced vaccines such as respiratory syncytial virus (RSV) remains suboptimal in many settings. Barriers include inconsistent counselling, safety concerns, misinformation, and structural inequities affecting access …

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Serum Metabolomic Signatures Indicate Oxidative Membrane Lipid Remodeling in β-Thalassemia

Alexandros C. Makis, Eleftheria ChR. Hatzimichael, Theodoros Palianopoulos, Dimitra Papagiannaki et autres

Background/Objectives: Oxidative stress and iron overload remodel erythrocyte membranes in β-thalassemia, but their systemic metabolic correlates are not well defined. We applied untargeted metabolomics to identify serum biomarkers reflecting these pathophysiological processes. Methods: Thirty-one adults with β-thalassemia [18 transfusion-dependent (TDT), 13 non-transfusion-dependent …

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Pediatric Evans Syndrome as a Multisystem Immune Disorder: A 13-Year Longitudinal Experience from a Single Academic Center

Dimitrios Karamitsos, Ioanna Paraskevi Papandrea, Nikoletta Rokidi, Ioanna Saougou et autres

Background: Pediatric-onset Evans syndrome (pES) is a rare autoimmune disorder defined by the coexistence or sequential development of immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA), frequently accompanied by autoimmune neutropenia (AIN) and characterized by a relapsing, multilineage course. Increasing evidence suggests …

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Serum Metabolomic Signatures Indicate Oxidative Membrane Lipid Remodeling in β-Thalassemia

Alexandros C. Makis, Eleftheria ChR. Hatzimichael, Theodoros Palianopoulos, Dimitra Papagiannaki et autres

Background/Objectives: Oxidative stress and iron overload remodel erythrocyte mem-branes in β-thalassemia, but their systemic metabolic correlates are not well defined. We applied untargeted metabolomics to identify serum biomarkers reflecting these patho-physiological processes. Methods: Thirty-one adults with β-thalassemia [18 transfu-sion-dependent (TDT), 13 non-transfusion-dependent …

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Determinants of human papillomavirus (HPV) vaccine uptake and health literacy regarding HPV infection and vaccine among undergraduate university students in Greece

Fani Ladomenou, Eleni Gorla, Michail Matalliotakis, Anastasios Serbis et autres

BACKGROUND/OBJECTIVES: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide. HPV vaccination is a safe and highly effective public health measure. Although the vaccine serves as a cancer-prevention tool and is easily accessible in most developed countries, vaccination coverage …

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Influenza-Associated Benign Acute Childhood Myositis During the 2024–2025 Season: A Retrospective Multicenter Study

Chrysoula Kosmeri, Margarita Efthalia Papasavva, Afroditi Kyrkou, Vasiliki Gketsi et autres

Background: The aim of this study was to describe the clinical and laboratory characteristics of hospitalized pediatric influenza cases during the 2024–2025 season in Northwestern Greece, with a focus on influenza-associated benign acute childhood myositis (BACM). Methods: We conducted a retrospective observational …

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Kikuchi–Fujimoto Disease: A Rare Etiology Behind Pediatric Cervical and Supraclavicular Lymphadenopathy: A Case Report

Maria E. Rogalidou, Vasileios G. Xydis, Kalliopi S. Stefanaki, Nikolaos Chaliasos et autres

Background and Clinical Significance: Cervical lymphadenopathy is a common condition in children, most often caused by reactive hyperplasia due to viral infections, followed by bacterial infections and, less commonly, malignancies. Supraclavicular lymphadenopathy in children warrants thorough evaluation due to its higher association …

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Kikuchi-Fujimoto Disease: A Rare Aetiology Behind Pediatric Cervical and Supraclavicular Lymphadenopathy

Maria E. Rogalidou, Kalliopi S. Stefanaki, Nikolaos Chaliasos, Alexandros C. Makis

Background: Cervical lymphadenopathy is a common condition in children. The most frequent cause is reactive hyperplasia due to viral infections, followed by bacterial infections and, rarely, malignancies. Supraclavicular lymphadenopathy in children warrants careful evaluation due to its higher risk of malignancy compared …

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Evaluation of risk factors for acute pyelonephritis and permanent renal damage (renal scarring) in children under 2 years of age with a first febrile urinary tract infection

Aikaterini Gkrepi, Anastasios Serbis, Vasileios I. Giapros, Chrysoula Kosmeri et autres

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SARS-CoV-2 Variants and Their Impact on Pediatric COVID-19: Clinical Manifestations and Hematological Profiles

Konstantinos Paris Trempelis, Chrysoula Kosmeri, Panagiotis Kalavas, Fani Ladomenou et autres

BACKGROUND: The aim of this study was to analyze data on pediatric cases of COVID-19 admitted to a tertiary referral hospital in northwest Greece. METHODS: A retrospective analysis was conducted on the most common clinical manifestations and laboratory findings, stratified by age …

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