Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing
Hojun Jung, Bada Jeong, Yong-Woo Kim, Chanju Jung et autres
Replacing large-scale fragments in human cells remains a substantial challenge. Here, we present a programmable gene replacement tool, named prime assembly (PA), which adapts prime editors to produce one or two pairs of 3'-flaps on both the genome and donor DNA. These …
kr, us, pr, am (code pays fourni par la source)