Kenneth E. Stebbins

A microRNA or messenger RNA point of departure estimates an apical endpoint point of departure in a rat developmental toxicity model

Kamin J. Johnson, Eduardo Costa, Valerie M. Marshall, Shreedharan Sriram et autres

Traditional developmental toxicity testing practice examines fetal apical endpoints to identify a point of departure (POD) for risk assessment. A potential new testing paradigm involves deriving a POD from a comprehensive analysis of molecular-level change. Here, the rat ketoconazole endocrine-mediated developmental toxicity …

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Mode-of-action and human relevance framework analysis for rat Leydig cell tumors associated with sulfoxaflor

Reza J. Rasoulpour, Claire Terry, Matthew J. LeBaron, Kenneth E. Stebbins et autres

Sulfoxaflor, a molecule that targets sap-feeding insects, was assessed for carcinogenic potential in groups of 50 Fischer rats fed with diets containing 0, 25, 100, 500 (males), or 750 (females) ppm sulfoxaflor for 2 years according to OECD 453. Sulfoxaflor did not …

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Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats following inhalation exposure

Darrell R. Boverhof, Shannon M. Krieger, Jon A. Hotchkiss, Kenneth E. Stebbins et autres

The immunotoxic potential of trichloroethylene (TCE) and perchloroethylene (PERC) was assessed after inhalation exposure through the evaluation of the antibody forming cell (AFC) response to sheep red blood cells (SRBC). Female Sprague-Dawley rats were exposed to TCE or PERC vapor at 0, …

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Initial Insights Regarding the Role of p53 in Maintaining Sperm DNA Integrity Following Treatment of Mice with Ethylnitrosourea or Cyclophosphamide

M. Sue Marty, Narendra P. Singh, Kenneth E. Stebbins, V. Ann Linscombe et autres

If p53 is essential to eliminate damaged spermatogenic cells, then mutagen exposure in the absence of p53 would increase sperm containing damaged DNA. p53 knockout (-/-, NULL) and wild-type (+/+, WT) mice (five/group) were exposed to ethylnitrosourea (ENU) or cyclophosphamide (CP). In …

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Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice

Lyle D. Burgoon, Qi Ding, Alhaji U. N′jai, Edward Dere et autres

Toxic equivalency factors (TEFs) are assigned to dioxin-like chemicals based on relative potency (REP) values of individual adaptive and toxic responses compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Agilent 4x44K oligonucleotide microarrays were used to examine the hepatic gene expression potency of 2,3,7,8-tetrachlorodibenzofuran (TCDF), relative …

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Comparative Temporal Toxicogenomic Analysis of TCDD- and TCDF-Mediated Hepatic Effects in Immature Female C57BL/6 Mice

Alhaji U. N′jai, Darrell R. Boverhof, Edward Dere, Lyle D. Burgoon et autres

Temporal analyses were performed on hepatic tissue from immature female C57BL/6 mice in order to compare the gene expression profiles for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibzofuran (TCDF). Time course studies conducted with a single oral dose of 300 microg/kg TCDF or 30 microg/kg …

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Nitrapyrin: A scientific advisory group review of the mode of action and carcinogenicity in B6C3F1 mice

Barry L. Yano, Jerry F. Hardisty, John Curtis Seely, Byron E. Butterworth et autres

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Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity☆

R. A. Corley, David J. D. Wilson, GC Hard, Kenneth E. Stebbins et autres

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STP Position Paper: Ovarian Follicular Counting in the Assessment of Rodent Reproductive Toxicity

Karen Regan, J. Mark Cline, Dianne M. Creasy, Barbara J. Davis et autres

Evaluation of the ovary is an important endpoint in tox-icological assessments because xenobiotics that cause lossof oogonia, oocytes, or supportive somatic cells may haveadverse effects on reproduction. To make an adequate histo-logic assessment of the ovary, knowledge of all morphologiccomponents and an …

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Factors affecting grip strength testing

Jacques P.J. Maurissen, Brian R. Marable, Amanda K. Andrus, Kenneth E. Stebbins

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PRELIMINARY STUDY TO TEST THE FEASIBILITY OF USING A LOCAL LYMPH NODE TYPE OF APPROACH TO CHARACTERIZE RESPIRATORY ALLERGENS

S.N. Goud, Phyllis K. Anderson, Connie M. Wiescinski, Kenneth E. Stebbins et autres

Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice

Kenneth E. Stebbins

The potential toxicologic and oncogenic effects of spinosad, a natural fermentation product with insecticidal properties, were investigated. The 13-week toxicity study consisted of groups of 10 CD-1 mice/sex provided diets containing 0, 0.005, 0.015, 0.045, or 0.12% spinosad (Study 1). The 0.12% …

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