Lorenzo Mortara

RNASET2 in chronic autoimmune thyroiditis

Daniela Gallo, Rossella Roncoroni, Eliana Piantanida, Chiaravalli Anna Maria et autres

Natural killer cells at the interface of tumor immune escape and immunotherapy resistance in endometrial cancer

Alessandro Poggi, Valentina Bruno, Anna Di Spirito, Lorenzo Mortara et autres

Endometrial cancer (EC) is characterized by significant molecular and immunological heterogeneity, which influences both disease progression and response to therapy. Although immune checkpoint blockade has improved the clinical management of selected EC subtypes, durable responses remain limited in many patients, particularly in …

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Editorial: Microbiota-immune interactions: a new frontier in cancer treatment optimization

Stephen Blake, Lorenzo Mortara, Sheila Spada

metabolism, promotion of DNA disfunction and abnormal cell growth resulting in gynecological cancers. They highlight the potential of microbiome with the microbial signature as non-invasive biomarkers and potential intervention including pre-and pro-biotics, modification of the diet, and, when possible, microbiota transplantation.Similarly, the …

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Impact of vitamin D plasma levels on in vitro natural killer cell cytotoxicity against non-small cell lung carcinoma in the presence of nivolumab

Federica Randisi, Sahar Balkhi, Lorenzo Mortara, Emanuela Marras et autres

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The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization

Martina Cucchiara, Maria Teresa Palano, Cristian Rubuano, Gianluca De Antoni et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality worldwide. Natural Killer (NKs) cells are pivotal for tumor surveillance but are dysfunctional in PDAC. We evaluated whether pharmacological blockade of TGF-β1/TGF-βR1 axis in PDAC cells and cancer-associated fibroblasts …

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Evolving frontiers in bladder cancer immunotherapy: integrating BCG, immune checkpoints, viral vectors, nanotechnology, and CAR-based therapies

Gaia Zuccolotto, Anna Tosi, Sahar Balkhi, Antonio Rosato et autres

Bladder cancer (BC) remains a prevalent malignancy with high recurrence rates despite standard therapies. Bacille Calmette-Guérin (BCG) is the cornerstone of treatment for non-muscle-invasive bladder cancer (NMIBC); however, nearly half of patients experience relapse or develop resistance, highlighting the need for alternative …

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Innate Priming and Tumor-Associated Macrophage Reprogramming: A Commentary on Emerging Immunotherapeutic Strategies

Sahar Balkhi, Lorenzo Mortara

IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to …

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Cancer prevention and interception with antidiabetic and anti-obesity drugs: Current and future perspectives

Adriana Albini, Anna Rita Cantelmo, Lorenzo Mortara, Douglas McClain Noonan et autres

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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners

Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria De Vito et autres

The identification of molecules that make cancer cells detectable by the immune system represents a major challenge in tumor immunology. Alarmins, endogenous, stress-induced molecules, serve as early warning signals triggering immune responses. The human RNASET2 protein has demonstrated both oncosuppressive and immunoregulatory …

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The Quest for Antibodies and Other Acquired Immune Receptors: A Historical Perspective

Andrea De Lerma Barbaro, Sahar Balkhi, Stefano Giovannardi, Alberto Vianelli et autres

The diversity of antibody molecules has for decades been an unsolved enigma that has attracted wide interest among biologists. Parallel to the accumulation of experimental evidence, progress in antibody research was also driven by the theoretical debate that played a particularly prominent …

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IP16-11 ANALYSIS OF CIRCULATING AND TUMOR-INFILTRATING NK CELLS IN RENAL CANCER PATIENTS: FOCUS ON FUNCTIONAL PROPERTIES AND PHENOTYPIC CHARACTERISTICS

Giorgia Bilato, Sara Baldini, Martina Cucchiara, R Bombelli et autres

CAR-NK cell therapy: promise and challenges in solid tumors

Sahar Balkhi, Gaia Zuccolotto, Antonio Rosato, Lorenzo Mortara

Over the past few years, cellular immunotherapy has emerged as a promising treatment for certain hematologic cancers, with various CAR-T therapies now widely used in clinical settings. However, challenges related to the production of autologous cell products and the management of CAR-T …

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