Georgy Kuznetsov

The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples

Maria Bograya, Maria Vulf, Anastasia Minchenko, Н. Д. Газатова et autres

Background: Epidermal growth factor receptor 4 (ERBB4) and neuregulin 4 (NRG4) have been shown to reduce steatosis and prevent the development of non-alcoholic steatohepatitis in mouse models, but little to nothing is known about their role in non-alcoholic fatty liver disease (NAFLD) …

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Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries

Giuseppe Fusai, Dimitri Aristotle Raptis, M.A. Hilal, Claudio Bassi et autres

BACKGROUND: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following …

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Stephen R Knight, Catherine A. Shaw, Riinu Pius, Thomas M Drake et autres

BACKGROUND: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between …

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CLINICAL AND STATISTICAL ASPECTS OF THE DEVELOPMENT AND COURSE OF BLEEDING FROM VARICOSE VEINS OF THE ESOPHAGUS IN PATIENTS WITH PORTAL HYPERTENSION

М. В. Трофімов, V. G. Korpusenko, S. O. Muntyan, Georgy Kuznetsov et autres

Summary. The aim of the study was to identify the main etiological factors that led to the development of portal hypertension — the leading cause of varicose bleeding, to analyze the clinical aspects of the course and methods of treatment of bleeding …

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Stephen R Knight, Caitlin Shaw, Riinu Pius, Thomas M Drake et autres

BACKGROUND: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the …

The types of left ventricular remodeling in patients with rheumatoid arthritis

I. A. Krivotulova, К. В. Корочина, Т. В. Чернышева, Georgy Kuznetsov et autres

Studying the factors leading to a pathological change in the cardiac structure in patients with rheumatoid arthritis (RA) can contribute to improvement in early diagnosis and to prevention of premature mortality from cardiovascular events.Objective. To study the types of left ventricular (LV) …

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Mathematical modeling of ischemic stroke

В. И. Ершов, A Chirkov, A. P. Gonchar-Zaykin, S. N. Lyashchenko et autres

Objective: to determine the prognostic value of the indicators of fluid and electrolyte balance in the acutest period of severe ischemic stroke (IS). Patients and methods. A total of 150 patients with severe IS of various locations and pathogenetic subtypes were examined. …

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