Jacopo Belfiore

Reply: Optimizing prognostic utility of ROTEM-assessed low fibrinolytic activity in liver transplantation—Key methodological adjustments

Jacopo Belfiore, Niccolò Castellani Nicolini, ML Bindi, Fuat H. SANER et autres

To the editor, We sincerely thank Dai et al for their thoughtful comments regarding our recently published study entitled “Evaluation of Low Fibrinolytic Activity by Rotational Thromboelastometry and Outcomes in Liver Transplantation: A Single-Centre Prospective Study.” We greatly appreciate the opportunity to …

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Sepsis in end-stage liver disease and acute-on-chronic liver failure: pathophysiology, diagnostic challenges, and pharmacological management

Jacopo Belfiore, Riccardo Taddei, L Suardi

Background: Sepsis represents a leading cause of acute decompensation, acute-on-chronic liver failure (ACLF), and short-term mortality in patients with end-stage liver disease (ESLD). Its clinical course is shaped by the coexistence of profound systemic inflammation, cirrhosis-associated immune dysfunction (CAID), and early multiorgan …

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Reply: Reconsidering fibrinolytic assessment and hemostatic management in liver transplantation

Jacopo Belfiore, N Castellani Nicolini, ML Bindi, F.H. Saner et autres

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Predicting massive blood transfusions in liver transplantation: the McCluskey Risk Index revised 20 years later.

Jacopo Belfiore, Gabriella Licitra, Alessandro Cardu, Maria Lucia Bindi et autres

BACKGROUND: Liver transplantation (LT) is a life-saving procedure for end-stage liver disease (ESLD), yet massive perioperative transfusions (MT) remain a significant concern. The McCluskey Risk Index (McRI), a widely used tool for predicting MT, was developed nearly two decades ago and does …

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Evaluation of low fibrinolytic activity by rotational thromboelastometry and outcomes in liver transplantation: A single-center prospective study

Jacopo Belfiore, Niccolò Castellani Nicolini, Maria Lucia Bindi, Fuat Hakan Saner et autres

Liver transplantation (LT) is a critical treatment for end-stage liver disease (ESLD) and is often complicated by hemostatic disturbances, including low fibrinolytic activity (LFA). LFA has been linked to adverse outcomes such as splanchnic thrombosis and increased perioperative mortality. This study aimed …

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Commentary on: Catecholamines in Sepsis: Pharmacological Insights and Clinical Applications – A Narrative Review

Jacopo Belfiore

The review by Belfiore et al. offers a comprehensive examination of catecholamine pharmacology and clinical application in septic shock, emphasizing their cardiovascular, metabolic, immunomodulatory, and endothelial effects. The authors highlight the dual role of catecholamines, which are essential for hemodynamic support yet …

Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review

Jacopo Belfiore, Riccardo Taddei, Gíanni Biancofiore

Catecholamines, essential neurotransmitters and hormones, play a critical role in the body's physiological response to stress and are pivotal in the management of various clinical conditions, particularly in critical care settings. This narrative review delves into the pharmacological properties of catecholamines, including …

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Transesophageal echocardiography monitoring for liver transplantation: where are we now?

Jacopo Belfiore, Michele Checchi, Niccolò Castellani Nicolini, Pietro Bertini et autres

Intraoperative hemodynamic monitoring is crucial for managing patients with end-stage liver disease (ESLD) undergoing orthotopic liver transplantation (OLT) due to their complex cardiovascular and pulmonary abnormalities. Traditionally, pulmonary artery catheterization (PAC) has been the standard for hemodynamic monitoring during OLT. However, the …

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Intrauterine transfusion experience at a tertiary care unit in foetal anaemia Parvovirus B19 related

Teresa Bordoni, Federica Manzoni, Gaia Scandella, Jacopo Belfiore et autres

Objective.Parvovirus B19 is a human pathogenic virus, which may cause a vertical transmitted infection, leading to foetal anaemia.It was associated with an outbreak in Italy in 2024.The objective is to evaluate the outcomes of intrauterine transfusions in foetuses affected by anaemia Parvovirus …

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Pain management in liver transplant recipients: a focus on current and future strategies

Jacopo Belfiore, Niccolò CASTELLANI NICCOLINI, Zachary J. Fleissner, Ryan Chadha et autres

Liver transplantation is the only curative treatment option for patients with end-stage liver disease. Anesthesiologists and intensivists are fully involved in this procedure due to the perioperative care focus on hemodynamic, respiratory and metabolic support. However, quite surprisingly, postoperative pain management does …

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Multimodal Pain Management of Liver Transplantation: What Is New?

Niccolò Castellani Nicolini, Jacopo Belfiore, Gíanni Biancofiore

Liver transplantation (LT) is a life-saving treatment representing the only viable option for patients suffering from end-stage liver disease (ESLD) or acute liver failure. Patients who undergo LT require a multidisciplinary approach to postoperative pain management. However, pain management in this context …

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The perioperative period of liver transplantation from unconventional extended criteria donors: data from two high-volume centres

Claudia Pescarissi, Beatrice Penzo, Davide Ghinolfi, Quirino Lai et autres

BACKGROUND: As literature largely focuses on long-term outcomes, this study aimed at elucidating the perioperative outcomes of liver transplant patients receiving a graft from two groups of unconventional expanded criteria donors: brain dead aged > 80 years and cardiac dead. METHODS: Data …

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