Edward J. Yurkow

Supplemental Figure 1: Overview of morphometric measurements

Samantha Adams, Michael J. Goedken, Marianne Polunas, Xiang Wang et autres

Supplemental Figure 1: Representative image of H&E stained heart used to illustrate the measurements made for morphometric assessment.

Supplemental Figure 1: Overview of morphometric measurements

Samantha Adams, Michael J. Goedken, Marianne Polunas, Xiang Wang et autres

Supplemental Figure 1: Representative image of H&E stained heart used to illustrate the measurements made for morphometric assessment.

Gestational exposure to micro and nanoplastics differentially impacts cardiac development and function in male and female rats throughout the lifespan

Chelsea M. Cary, Samantha E. Adams, Gina M. Moreno, Talia Seymore et autres

Micro- and nanoplastics (MNPs) are a ubiquitous contaminant. Identification of MNPs in the human placenta suggests this toxicant poses a danger to developing offspring. Previously, we demonstrated that maternal pulmonary MNP exposure restricts fetal growth and disrupts fetoplacental cardiovascular function in rats. …

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Chronic Inhalation of Ultrafine Particulate Matter Results in a Peripartum Cardiomyopathy-like Phenotype in Pregnant Sprague Dawley Rats

Samantha E. Adams, Xiang Wang, Edward J. Yurkow, Phoebe A. Stapleton

Peripartum Cardiomyopathy (PPCM) is a leading cause of maternal death world-wide. It is diagnosed in the last month of pregnancy or 6 months after delivery as left ventricle systolic dysfunction, including significant (10 - 20%) reductions in ejection fraction and fractional shortening …

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Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function

Chelsea M. Cary, Sara Fournier, Sarah E. Adams, Xiaoming Wang et autres

Large-scale production and waste of plastic materials have resulted in widespread environmental contamination by the breakdown product of bulk plastic materials to micro- and nanoplastics (MNPs). The small size of these particles enables their suspension in the air, making pulmonary exposure inevitable. …

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Comparison of pharmaceutical properties and biological activities of prednisolone, deflazacort, and vamorolone in DMD disease models

Grace Liu, Philip Lipari, Anna Mollin, Stephen P. Jung et autres

Duchenne muscular dystrophy (DMD) is a progressive disabling X-linked recessive disorder that causes gradual and irreversible loss of muscle, resulting in early death. The corticosteroids prednisone/prednisolone and deflazacort are used to treat DMD as the standard of care; however, only deflazacort is …

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Data from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig, Robert W. Tuman et autres

Abstract There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Herein, we report the efficacy of a novel orally …

Data from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig, Robert W. Tuman et autres

Abstract There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Herein, we report the efficacy of a novel orally …

Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig, Robert W. Tuman et autres

Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Carl L. Manthey, Dana L. Johnson, Carl R. Illig, Robert W. Tuman et autres

Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Relationship between Body Composition and Serum Immunoglobulin Concentrations after Administration of Intravenous Immune Globulin–Preclinical and Clinical Evidence

Luigi Brunetti, Hélène Chapy, Ronald Nahass, Rebecca Maldonado Moore et autres

The purpose of this study was to investigate the effect of obesity on immunoglobulin G (IgG) pharmacokinetics in a rat model of obesity, and to collect clinical evidence for an association between the body composition and intravenous immune globulin (IVIG) pharmacokinetic parameters …

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Assessment of mustard vesicant lung injury and anti‐TNF‐α efficacy in rodents using live‐animal imaging

Alexa Murray, Andrew J. Gow, Alessandro Venosa, Jaclynn Andres et autres

Nitrogen mustard (NM) causes acute lung injury, which progresses to fibrosis. This is associated with a macrophage-dominant inflammatory response and the production of proinflammatory/profibrotic mediators, including tumor necrosis factor alpha (TNF-α). Herein, we refined magnetic resonance imaging (MRI) and computed tomography (CT) …

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