Harr Freeya Njai

Clinical characteristics and outcomes of patients with cirrhosis and hepatocellular carcinoma in The Gambia, west Africa: a prospective cohort study

Gibril Ndow, Erwan Vo Quang, Yusuke Shimakawa, Amie Ceesay et autres

BACKGROUND: Chronic liver disease is a major cause of premature death in sub-Saharan Africa. Efficacy of antiviral therapy among patients with hepatitis B virus (HBV)-related cirrhosis is not well established in Africa. We described the clinical characteristics and outcomes of patients with …

Gambie, fr, gb (code pays fourni par la source)

Clinical Characteristics and Outcomes of Patients with Cirrhosis and Hepatocellular Carcinoma in the Gambia, West Africa

Gibril Ndow, Erwan Vo Quang, Yusuke Shimakawa, Amie Ceesay et autres

Gambie, fr, gb, ch, ca (code pays fourni par la source)

Hepatitis B Core-related Antigen: An Alternative to Hepatitis B Virus DNA to Assess Treatment Eligibility in Africa

Yusuke Shimakawa, Gibril Ndow, Ramou Njie, Harr Freeya Njai et autres

BACKGROUND: To eliminate hepatitis B virus (HBV) infection, it is essential to scale up testing and treatment. However, conventional tools to assess treatment eligibility, particularly nucleic acid testing (NAT) to quantify HBV DNA, are hardly available and affordable in resource-limited countries. We …

fr, Gambie, gb, jp (code pays fourni par la source)

Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa

Yusuke Shimakawa, Ramou Njie, Gibril Ndow, Muriel Vray et autres

BACKGROUND & AIMS: To eliminate hepatitis B virus (HBV) infection, it is essential to scale up antiviral treatment through decentralized services. However, access to the conventional tools to assess treatment eligibility (liver biopsy/Fibroscan®/HBV DNA) is limited and not affordable in resource-limited countries. …

fr, Gambie, gb, Sénégal, Burkina Faso, de (code pays fourni par la source)

HIV-1 transmission networks in high risk fishing communities on the shores of Lake Victoria in Uganda: A phylogenetic and epidemiological approach

Sylvia Kiwuwa-Muyingo, Jamirah Nazziwa, Deogratius Ssemwanga, Pauliina Ilmonen et autres

BACKGROUND: Fishing communities around Lake Victoria in sub-Saharan Africa have been characterised as a population at high risk of HIV-infection. METHODS: Using data from a cohort of HIV-positive individuals aged 13-49 years, enrolled from 5 fishing communities on Lake Victoria between 2009-2011, …

Ouganda, fi, us, gb (code pays fourni par la source)

Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

Maud Lemoine, Yusuke Shimakawa, Ramou Njie, Makie Taal et autres

BACKGROUND: Despite the introduction of immunisation for hepatitis B virus (HBV) in the 1990s, HBV-related morbidity and mortality remain high in sub-Saharan Africa. Identification and treatment of asymptomatic people with chronic HBV infection should reduce the disease burden. We therefore assessed the …

Gambie, gb, fr, Sénégal, nl (code pays fourni par la source)

Cost-effectiveness of community-based screening and treatment for chronic hepatitis B in The Gambia: an economic modelling analysis

Shevanthi Nayagam, Lesong Conteh, Elisa Sicuri, Yusuke Shimakawa et autres

BACKGROUND: Despite the high burden of hepatitis B virus (HBV) infection in sub-Saharan Africa, absence of widespread screening and poor access to treatment leads to most people remaining undiagnosed until later stages of disease when prognosis is poor and treatment options are …

gb, es, fr, Gambie (code pays fourni par la source)

Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia

Yusuke Shimakawa, Maud Lemoine, Harr Freeya Njai, Christian Bottomley et autres

BACKGROUND: The natural history of chronic HBV infection in sub-Saharan Africa is unknown. Data are required to inform WHO guidelines that are currently based on studies in Europe and Asia. METHODS: Between 1974 and 2008, serosurveys were repeated in two Gambian villages, …

fr, gb, Gambie (code pays fourni par la source)

Hepatitis B: The view from West Africa

Mario Lepore, Harr Freeya Njai, Deborah A. Garside, Yusuke Shimakawa et autres

The Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study began in 2011 in The Gambia, Sénégal and Nigeria. The study aims to reduce the risk of hepatocellular carcinoma (HCC) in West Africa through the suppression of the Hepatitis B virus …

gb (code pays fourni par la source)

P0598 : Natural history of chronic hepatitis B infection in The Gambia, West Africa: A longitudinal population-based study

Yusuke Shimakawa, Maud Lemoine, Christian Bottomley, Harr Freeya Njai et autres

fr, gb, Gambie (code pays fourni par la source)

Birth order and risk of hepatocellular carcinoma in chronic carriers of hepatitis B virus: a case–control study in The Gambia

Yusuke Shimakawa, Maud Lemoine, Christian Bottomley, Harr Freeya Njai et autres

BACKGROUND & AIMS: Early age at infection with Hepatitis B virus (HBV) increases the risk of chronic infection. Moreover, early HBV infection may further independently increase the risk of hepatocellular carcinoma (HCC) beyond its effect on chronicity. METHODS: The distribution of birth …

fr, gb, Gambie (code pays fourni par la source)

Validation of Rapid Point-of-Care (POC) Tests for Detection of Hepatitis B Surface Antigen in Field and Laboratory Settings in the Gambia, Western Africa

Harr Freeya Njai, Yusuke Shimakawa, Bakary Sanneh, Lynne Ferguson et autres

Hepatitis B virus (HBV) infection is a leading cause of death in sub-Saharan Africa (SSA). Point-of-care tests for hepatitis B surface antigen (HBsAg) could be an ideal tool for a large-scale HBV screening/treatment program in SSA. Using data from the PROLIFICA (Prevention …

Gambie, jp, fr, Sénégal, gb (code pays fourni par la source)