Kongdi Zhu

From Single Nutrients to Networked Health: Micronutrients and Bioactive Molecules in Development, Interaction, and Clinical Translation

Jiaqiang Huang, Kongdi Zhu

Micronutrients, including essential minerals and vitamins, together with bioactive molecules such as polyphenols, flavonoids, and milk-derived proteins, are fundamental to human health [...].

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ROS-Responsive Hydrogel Delivering Bio-Nanoselenium for Targeted Therapy of UVB-Induced Skin Photodamage

Kongdi Zhu, Jiamin Zhao, Tong Li, Shidi Zhang et autres

Ultraviolet B (UVB) radiation is a major environmental factor that induces skin photodamage through oxidative stress and inflammation. To address this, we developed a reactive oxygen species (ROS)-responsive hydrogel, SeNPs@HPTA, for the intelligent delivery of biogenic selenium nanoparticles (BioSeNPs) synthesized by Bifidobacterium …

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Selenium-Biofortified Probiotics: A Synergistic Microbial–Nutritional Strategy Against Exercise-Induced Stress

Qi Wang, Jinjin Xing, Yujing Huang, Jiaqiang Huang et autres

This review aims to explore the potential and mechanisms of selenium-biofortified probiotics as an innovative nutritional strategy for alleviating exercise-induced physiological stress. Exercise, particularly high-intensity or exhaustive exercise, triggers a cascade of physiological perturbations, including oxidative stress, inflammatory responses, gut barrier dysfunction, …

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Towards Precision and Balance in Selenium Nutrition: From Innovation to Application

Jiaqiang Huang, Kongdi Zhu

Selenium (Se) is an essential trace element for human health, primarily functioning through its incorporation into selenoproteins, which play critical roles in antioxidant defense, immune regulation, and thyroid hormone metabolism [...].

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The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health

Qi Wang, Ruiyang Gao, Kongdi Zhu, Huilong Qiu et autres

Iron is an essential trace element that participates in multiple physiological processes, including oxygen transport, electron transfer, DNA synthesis, and red blood cell production. Iron loss is particularly severe among athletes, so maintaining iron homeostasis is crucial for sports nutrition and health. …

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Selenium-enriched Lactobacillus coryniformis H8 alleviates LPS-induced jejunal injury in chicks by modulating antioxidant activity, inflammation, selenoprotein genes, and gut microbiota

Zijian Xu, Dan Xiao, Ke Chen, Jingli Han et autres

Intestinal inflammation in chicks remains a prevalent health concern, highlighting the importance of developing effective alternatives to conventional antibiotics. This study aimed to investigate the effect of selenium-enriched Lactobacillus coryniformis H8 (Se-H8) in alleviating lipopolysaccharides (LPS)-induced intestinal inflammation in chicks and the …

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Selenium and Skeletal Muscle Health in Sports Nutrition

Qi Wang, Jiaqiang Huang, Kongdi Zhu, Wei Zuo

Selenium is a trace element of fundamental importance to human health. In recent years, an increasing number of studies have been carried out in the field of skeletal muscle health and sports nutrition. Selenium functions in the human body through selenoproteins. Selenoproteins …

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Amelioration of LPS-Induced Jejunum Injury and Mucus Barrier Damage in Mice by IgY Embedded in W/O/W Emulsion

Zhaohui Wang, Ruihua Ye, Shidi Zhang, Chuanming Liu et autres

Chicken yolk immunoglobulin (IgY) is a natural immunologically active antibody extracted from egg yolk and can be used as a natural dietary supplement for the treatment of inflammation and damage to the intestines. In our study, IgY was embedded in a double …

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Protective Effect of IgY Embedded in W/O/W Emulsion on LPS Enteritis-Induced Colonic Injury in Mice

Zhaohui Wang, Ruihua Ye, Zijian Xu, Shidi Zhang et autres

Chicken yolk immunoglobulin (IgY), an immunologically active component, is used as an alternative to antibiotics for the treatment of enteritis. In this study, IgY was embedded in a W/O/W emulsion to overcome the digestive barrier and to investigate the protective effect of …

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SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer (Adv. Sci. 28/2024)

Xin Huang, Yang Xu, Mingxin Zhang, Tong Li et autres

New Therapeutic Strategies for Colitis and Colorectal Cancer In article number 2404073, Cong Lv, Jiaqiang Huang, and co-workers depict the inhibition of ferroptosis by SELENOI in intestinal epithelial cells through Chinese mythology “Dayu tamed the flood”. In this study, SELENOI (Dayu) regulates …

SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer

Xin Huang, Yang Xu, Mingxin Zhang, Tong Li et autres

Ferroptosis plays important roles both in normal physiology and multiple human diseases. It is well known that selenoprotein named glutathione peroxidase 4 (GPX4) is a crucial regulator for ferroptosis. However, it remains unknown whether other selenoproteins responsible for the regulation of ferroptosis, …

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Biomimetic MicroRNAs‐Selenium‐Nanocomposites for Targeted and Combined Hyperlipidemia Therapy

Tong Li, Libing Liu, Kongdi Zhu, Luo Yun et autres

Hyperlipidemia is considered as a high-risk factor for leading to coronary heart disease. MicroRNA-148a-3p (miR-148a-3p) inhibitor is a potential therapeutic target to bind low-density lipoprotein cholesterol receptors (LDLR) for decreasing the levels of low-density lipoprotein cholesterol in plasma. However, the therapeutic effects …

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