D.M. Becker

Rare genetic variants explain missing heritability in smoking

Marilyn J. Telen, Z. Wang, Brenda W. Campbell Jenkins, Shannon Kelly et autres

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this ‘missing heritability’. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up …

us (code pays fourni par la source)

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Lawrence F. Bielak, B.M. Psaty, Juan M. Peralta, R. Graham Barr et autres

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new …

us (code pays fourni par la source)

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Wei Zheng, Jennifer G. Robinson, M.A. Richard, K. Schwander et autres

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the …

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Frits R. Rosendaal, Hugues Aschard, Kurt K. Lohman, Jiang He et autres

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci …

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Ken Rice, Lisa W. Martin, Chen-Huan Yu, Pamela J. Schreiner et autres

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In …

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

S.E. Harris, J. Corley, M.K. Wojczynski, M. Nauck et autres

Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the CHARGEmtDNA+ Consortium, we studied genetic associations of mtDNA and MT-nDNA associations with body mass index …

in, us (code pays fourni par la source)

Interaction of Body Mass Index and Framingham Risk Score in Predicting Incident Coronary Disease in Families

Sergio de la Mora, L.R. Yanek, T.F. Moy, D. Fallin et autres