Puja Singh

Abstract 4225: AI-driven de novo design of humanized nanobodies targeting KLK2 for prostate cancer immunotherapy

Fengze Jin, Puja Singh, Hanyong Chen, Christopher A. Warlick et autres

Abstract Conventional monoclonal antibodies (mAbs) are widely used in cancer therapy but are limited by large size (∼150 kDa), structural complexity, and high production costs, motivating the development of alternative antibody formats. Single-chain variable fragments (scFvs), derived from mAbs, retain antigen-binding specificity …

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Abstract 5477: AI-driven de novo design of miniproteins targeting mutant p53 peptide-MHC-I complex for cancer immunotherapy.

Fengze Jin, Puja Singh, Hanyong Chen, Christopher A. Warlick et autres

Abstract Genetic alterations in the tumor suppressor p53 occur in nearly every type of human cancer, with mutation rates ranging from 10% to nearly 100%, averaging about 50% in cancer patients. Over 80% of these mutations are missense mutations in the p53 …

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Abstract 7437: AI-guided discovery of small molecules targeting eIF4F complex to inhibit oncogenic mRNA translation in castration-resistant prostate cancer

Puja Singh, Hanyong Chen, Yibin Deng

Abstract Effective treatment of castration-resistant prostate cancer (CRPC) remains a significant clinical challenge. Our structure-guided biochemical studies have revealed that the interaction between eukaryotic initiation factors eIF4A and eIF4G within the eIF4F complex plays an essential role for prostate cancer cell survival …

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Nanopriming with phytofabricated selenium nanoparticles alleviates arsenite-induced oxidative stress in Spinacia oleracea L

Amit Kumar, Garima Jain, Prasanna Dutta, Puja Singh et autres

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TARGETING ABSOLUTE LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL) REDUCTION AS A BETTER APPROACH THAN STARTING STATINS BASED ON INITIAL BASELINE LDL FOR PRIMARY PREVENTION OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE AND MORTALITY: A METAREGRESSION

Bishnu Mohan Singh, Nisha Singh, Anuradha Raut, Puja Singh et autres

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Evaluation of the Antimicrobial Activity of Magnetized Water and Its Comparison with Chlorhexidine 0.2% in Young Children for 3 Weeks

Neha Kumari, Sumaiya Nezam, Puja Singh, Neelu Kumari et autres

AIM: The goal of this study was to compare the effects of magnetized water and 0.2% chlorhexidine mouthwash on gingivitis and plaque prevention in children aged 12-15 years for a period of 21 days. MATERIALS AND METHODS: A total of 24 youngsters …

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Aurora A site specific TACC3 phosphorylation regulates astral microtubule assembly by stabilizing γ-tubulin ring complex

Resmi Rajeev, Puja Singh, Ananya Asmita, Ushma Anand et autres

BACKGROUND: Astral microtubules emanating from the mitotic centrosomes play pivotal roles in defining cell division axis and tissue morphogenesis. Previous studies have demonstrated that human transforming acidic coiled-coil 3 (TACC3), the most conserved TACC family protein, regulates formation of astral microtubules at …

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Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

Liping Dou, Fei Yan, Jiuxia Pang, De‐Hua Zheng et autres

The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that …

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Abstract 4391: Disruption of the translation initiation complex by eIF4A mutant inhibits prostate tumor growth in vivo

Puja Singh, Hanyong Chen, Hanxuan Li, Young‐In Chi et autres

Abstract Translation initiation in cancer cells is the rate-limiting step of oncogenic mRNAs translation/protein synthesis and is primarily mediated by the eukaryotic translation initiation factor 4 F (eIF4F) complex that consists of three subunits: eIF4E, which binds the cap of mRNA; eIF4A, …

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Abstract 4391: Disruption of the translation initiation complex by eIF4A mutant inhibits prostate tumor growthin vivo

Puja Singh, Hanyong Chen, Hanxuan Li, Young‐In Chi et autres

Translation initiation in cancer cells is the rate-limiting step of oncogenic mRNAs translation/protein synthesis and is primarily mediated by the eukaryotic translation initiation factor 4 F (eIF4F) complex that consists of three subunits: eIF4E, which binds the cap of mRNA; eIF4A, an …

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Abstract 4447: Structural basis of human translation initiation factor eIF4G-enhanced helicase activity of eIF4A in tumorigenesis

Puja Singh, Hanyong Chen, Young‐In Chi, Junxuan Lü et autres

Abstract Dysreguated translation of tumor suppressor gene and/or oncogene mRNAs into proteins plays a crucial role in tumorigenesis. Translation initiation in mammalian cells is the rate-limiting step of mRNA translation/protein synthesis and primarily exerted through the eukaryotic translation initiation factor 4 F …

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SnapShot: Functions of Tubulin Posttranslational Modifications

Maria M. Magiera, Puja Singh, Carsten Janke

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