Heinke Kunst

Tuberculous meningitis with hydrocephalus: A retrospective case series in a UK hospital

Ali M. Alam, Yasmin Milner, Akanksha Mimi Malhotra, C. Brito Suárez et autres

Background Patients may show signs of ventricular enlargement in the early stages of tuberculous meningitis (TBM), and the presence of hydrocephalus is a poor prognostic marker. There is limited evidence on the features which may suggest development of hydrocephalus in TBM (TBMH). …

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Evolution of the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones

Carolin T. Turner, Andreas Tiffeau-Mayer, Joshua Rosenheim, Aneesh Chandran et autres

T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the temporal evaluation of the human in vivo clonal repertoire of Mycobacterium tuberculosis (Mtb)-reactive T cell responses, by …

gb, dk, de, Afrique du Sud, us, ca (code pays fourni par la source)

Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study

Berit Lange, Thomas Theo Brehm, Sandra M. Arend, Miguel Arias-Guillén et autres

BACKGROUND: Solid organ transplant (SOT) recipients face elevated tuberculosis risk, yet optimal prevention strategies in low- to medium-incidence regions remain unclear. METHODS: We conducted a multicenter retrospective cohort study of adult SOT recipients transplanted between 2007 and 2012 at 15 European centers, …

de, nl, es, us, gb, pt, br, at, Afrique du Sud, rs, cz (code pays fourni par la source)

Query into Tuberculosis Infection Screening and Management among Pregnant Migrants, Europe

Filippo Cioli Puviani, Amina Zaffagnini, Cristina Mazzi, Daniela Maria Cirillo et autres

Pregnant migrant women face increased tuberculosis vulnerability. We queried clinicians in Europe on Mycobacterium tuberculosis infection screening and management among pregnant migrants. Fewer than half reported routinely performing screening, and diagnostic and preventive practices varied widely. Those responses highlight substantial heterogeneity and …

S80 A cluster-randomised evaluation of a theory-based intervention to help people with TB disease get the most from their treatment and care: the IMPACT feasibility study

EF Walker, Zachary Moon, CNJ Campbell, Caroline Sarah Clarke et autres

Introduction and Objectives Treatment for tuberculosis (TB) with multiple, potentially toxic, drugs lasts months but will cure >90% with drug sensitive TB, if taken as prescribed. Non-adherence inevitably occurs, and most methods to improve adherence use medication ‘reminders’ or supervised treatment that …

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Predictive value of pre-test clinical diagnosis for mediastinal lymphadenopathy compared to histological outcomes from cervical mediastinoscopy

Kerry Woolnough, Maninder Singh Kalkat, Heinke Kunst

OBJECTIVE To compare pre-test diagnoses of mediastinal lymphadenopathy with histology obtained from cervical mediastinoscopy. METHODS Retrospective study of cervical mediastinoscopy outcomes between January 2009 and January 2011. We classified patients by histology and elicited whether the pre-test diagnosis was confirmed, supported or …

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