Frederik Sirgel

Melting the eis : Nondetection of Kanamycin Resistance Markers by Routine Diagnostic Tests and Identification of New eis Promoter Variants

Serej D. Ley, Samantha Pillay, Elizabeth Maria Streicher, Yuri F. van der Heijden et autres

Eis promoter mutations can confer reduced Mycobacterium tuberculosis kanamycin susceptibility. GenoType MTBDR sl, a widely used assay evaluating this region, wrongly classified 17/410 isolates as eis promoter wild type.

Afrique du Sud, ch, us (code pays fourni par la source)

Isoniazid Activity Is Terminated by Bacterial Persistence

Denis Anthony Mitchison, Amina Jindani, Geraint Davies, Frederik Sirgel

We welcome the application of rigorous in vitro pharmacokinetic-pharmacodynamic methods by Gumbo et al. in their attempt to explain the time course of sputum colony counts during isoniazid monotherapy [1]. However, their conclusion that the rapid emergence of isoniazid-resistant mutants is responsible …

gb, Afrique du Sud (code pays fourni par la source)

Involvement of the katG and rpoB genes of M. tuberculosis in isoniazid and rifampicin resistant clinical isolates

T. C. Victor, G S Pretorius, Frederik Sirgel, Paul D. van Helden