Friederike Münn

Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-19

Charlotte Thibeault, Lara Bardtke, Kanika Vanshylla, Veronica Di Cristanziano et autres

BACKGROUNDAfter its introduction as standard-of-care for severe COVID-19, dexamethasone has been administered to a large number of patients globally. Detailed knowledge of its impact on the cellular and humoral immune response to SARS-CoV-2 remains scarce.METHODSWe included immunocompetent individuals with (a) mild COVID-19, …

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Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis

Tilman Lingscheid, Martina Kinzig, Anne Krüger, Nils B. Müller et autres

Nirmatrelvir/ritonavir is an effective antiviral therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Use is not recommended in patients with end-stage renal disease (ESDR) due to a lack of data. We investigated the pharmacokinetics of nirmatrelvir/ritonavir (150 mg/100 mg twice a …

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Pharmacokinetics of nirmatrelvir and ritonavir in COVID-19 patients with end stage renal disease on intermittent haemodialysis

Tilman Lingscheid, Martina Kinzig, Anne Krüger, Nils B. Müller et autres

Abstract Background Nirmatrelvir/ritonavir is an effective therapy against SARS-CoV-2. Patients with end-stage renal disease (ESRD) are at high risk for severe COVID-19 and show impaired vaccine responses underlining the importance of antiviral therapy. However, use of nirmatrelvir/ritonavir is not recommended in these …

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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns

Henning Gruell, Kanika Vanshylla, Michael Korenkov, Pinkus Tober‐Lau et autres

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Delineating antibody escape from Omicron sublineages

Henning Gruell, Kanika Vanshylla, Michael Korenkov, Pinkus Tober‐Lau et autres

Abstract SARS-CoV-2 neutralizing antibodies play a critical role in prevention and treatment of COVID-19 but are challenged by viral evolution and antibody evasion, exemplified by the highly resistant Omicron BA.1 sublineage. 1–12 Importantly, the recently identified Omicron sublineages BA.2.12.1 and BA.4/5 with …

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Durability of Omicron-neutralizing serum activity following mRNA booster immunization in elderly individuals

Kanika Vanshylla, Pinkus Tober‐Lau, Henning Gruell, Friederike Münn et autres

Abstract Elderly individuals are at high risk for severe COVID-19. Due to modest vaccine responses compared to younger individuals and the time elapsed since prioritized vaccinations, the emerging immune-evasive Omicron variant of SARS-CoV-2 is a particular concern for the elderly. Here we …

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A survey among physicians in surgery and anesthesiology departments after the first surge of SARS-CoV-2 infections in Germany

A. V. Grishina, Fabian Link, Arne Arend, Florentine Kleemann et autres

BACKGROUND: The SARS-CoV‑2 pandemic has extensively challenged healthcare systems all over the world. Many elective operations were postponed or cancelled, changing priorities and workflows in surgery departments. AIMS: The primary aim of this cross-sectional study was to assess the workload and psychosocial …

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Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

Kanika Vanshylla, Chengcheng Fan, Marie Wunsch, Nareshkumar Poopalasingam et autres

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Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

David Hillus, Tatjana Schwarz, Pinkus Tober‐Lau, Kanika Vanshylla et autres

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Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February–March 2021

Pinkus Tober‐Lau, Tatjana Schwarz, David Hillus, Jana Spieckermann et autres

One week after second vaccinations were administered, an outbreak of B.1.1.7 lineage severe acute respiratory syndrome coronavirus 2 infections occurred in a long-term care facility in Berlin, Germany, affecting 16/20 vaccinated and 4/4 unvaccinated residents. Despite considerable viral loads, vaccinated residents experienced …

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Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Tatjana Schwarz, Pinkus Tober‐Lau, David Hillus, Elisa T. Helbig et autres

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial …

Detection of missed fractures of hand and forearm in whole-body CT in a blinded reassessment

Simon Kim, Leonie Goelz, Friederike Münn, D. Kim et autres

BACKGROUND: We examined the visibility of fractures of hand and forearm in whole-body CT and its influence on delayed diagnosis. This study is based on a prior study on delayed diagnosis of fractures of hand and forearm in patients with suspected polytrauma. …

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