Aurore Grelier

Physical fitness and chronic low back pain: A case-control study including 517 individuals

J. Beaudreuil, Aurore Grelier, O. Bailliart, A. Yelnik et autres

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Increased Risk of Serious Bacterial Infections Due to Maternal Immunosuppression in HIV-Exposed Uninfected Infants in a European Country

Clément Taron-Brocard, Jérôme Le Chenadec, Albert Faye, Catherine Dollfus et autres

BACKGROUND: Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated the possible association between maternal immune depression during pregnancy and the risk …

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Sex chromosome loss may represent a disease‐associated clonal population in chronic lymphocytic leukemia

Élise Chapiro, Iléana Antony‐Debré, Nathalie Marchay, Christophe Parizot et autres

Whether sex chromosome loss (SCL) is an age-related phenomenon or a cytogenetic marker of hematological disease is unclear. To address this issue in chronic lymphocytic leukemia (CLL), we investigated 20 cases with X or Y chromosome loss detected by conventional cytogenetics (CC). …

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P53 Functional Assessment and Correlation With 17p Deletion and/Or TP53 Mutation Status In Chronic Lymphocytic Leukemia (CLL). A Preliminary Report Of The ICLL001 Bomp Trial On Behalf Of The French CLL Intergroup (GCFLLC/MW - GOELAMS)

Magali Le Garff‐Tavernier, Lauren Véronèse, Florence Nguyen‐Khac, Marie‐Sarah Dilhuydy et autres

Abstract Despite improvement in treatment strategies, virtually all chronic lymphocytic leukemia (CLL) patients will relapse and experience tumor resistance. The 17p deletion resulting in loss of the TP53 gene, found in up to 20-40% of relapsing patients, is strongly associated with impaired …

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Soluble CD23 measurement by CBA: A convenient and reliable quantification method in chronic lymphocytic leukemia

Aurore Grelier, Magali Le Garff‐Tavernier, Frans A. Nauwelaers, Marika Sarfati et autres

The soluble form of the transmembrane glycoprotein CD23 corresponding to the low-affinity receptor for the immunoglobulin E (sCD23) is found in the serum of patients with chronic lymphocytic leukemia (CLL). In this disease, an increase in sCD23 level is predictive of poor …

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Soluble CD23 measurement by CBA: A convenient and reliable quantification method in Chronic Lymphocytic Leukemia

Aurore Grelier, Magali Le Garff‐Tavernier, F. Nauwelaers, M. Sarfati et autres

The soluble form of the transmembrane glycoprotein CD23 corresponding to the low-affinity receptor for the immunoglobulin E (sCD23) is found in the serum of patients with chronic lymphocytic leukemia (CLL). In this disease, an increase in sCD23 level is predictive of poor …

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Antibody-dependent cellular cytotoxicity of the optimized anti-CD20 monoclonal antibody ublituximab on chronic lymphocytic leukemia cells with the 17p deletion

Magali Le Garff‐Tavernier, Linda Herbi, Christophe de Romeuf, Florence Nguyen‐Khac et autres

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Toll-like receptor 3 regulates cord blood-derived endothelial cell function in vitro and in vivo

Aurore Grelier, Audrey Cras, Nicole Balitrand, Catherine Delmau et autres

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Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

Florence Nguyen‐Khac, Jérôme Lambert, Élise Chapiro, Aurore Grelier et autres

Waldenström's macroglobulinemia is a disease of mature B cells, the genetic basis of which is poorly understood. Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known. We conducted a prospective cytogenetic study of Waldenström's macroglobulinemia and examined …

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Sex Chromosome Loss May Represent a Disease-Associated Clonal Population in Chronic Lymphocytic Leukemia (CLL),

Iléana Antony‐Debré, Nathalie Marchay, Christophe Parizot, Élise Chapiro et autres

Abstract Abstract 3534 Sex chromosome loss is observed in the healthy population and increases with advancing age. It is also observed in hematological malignancies with variable clinical value. Its significance as a disease marker in CLL is not clearly defined. We undertook …

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2.41 Clinical Significance of Sex Chromosome Loss in Chronic Lymphocytic Leukemia

Iléana Antony‐Debré, Nathalie Marchay, Christophe Parizot, Élise Chapiro et autres

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Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia.

Florence Nguyen‐Khac, Élise Chapiro, Claude Lesty, Aurore Grelier et autres

BACKGROUND: Chromosomal translocations are usually analyzed as a single entity, and are associated with a poor outcome in chronic lymphocytic leukemia. Translocations involving immunoglobulin genes are recurrent, but uncommon (<5%), and their individual prognosis is not clear. The two most frequent partners …