Chung Sim Lim

As Venous Lesions Advance, So Does Radiation

Chung Sim Lim, Stephen Alan Black

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Iliac vein morphology and wall shear stress: a statistical shape modelling and CFD analysis of patient-specific geometries

Magdalena Otta, Karol Zając, Ian Halliday, Chung Sim Lim et autres

Abstract Deep vein thrombosis (DVT) is a prevalent vascular condition in which venous anatomy and flow disturbances contribute to the risk of thrombosis, but the mechanistic links between vessel shape and haemodynamics remain poorly quantified. Although computational fluid dynamics (CFD) can estimate …

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Congenital Subclavian Vein Aneurysm in an Infant

C.E. Rutter, Tjasa Zaletel, Premal Amrishkumar Patel, Kishore Minas et autres

Congenital thoracic lymphovenous aneurysms are exceedingly rare. They often present with compressive symptoms or thrombosis, necessitating surgical excision for symptom relief and cosmetic reasons. We report a symptomatic subclavian vein aneurysm in a 4-month-old infant who presented with a rapidly enlarging axillary …

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Shape vs Flow: A 2D Statistical Shape Analysis of the Projection of Common Iliac Veins in Patients with Deep Vein Thrombosis

Magdalena Otta, Karol Zając, Maciej Malawski, Ian Halliday et autres

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Evolving medical treatment for vascular malformation

Calver Pang, Rebecca Lee, Rebecca Nisbet, George Hamilton et autres

Vascular malformations are abnormal growth or development of the vascular structure that result from genetic mutations during early vascular development. Traditional invasive treatment for vascular malformations includes embolo-sclerotherapy, cryotherapy, laser therapy and surgery. However, surgical or minimally invasive treatment is rarely optimal …

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Oral sirolimus therapy for patients with complex low-flow vascular malformations

Rebecca Nisbet, Calver Pang, Nicholas Evans, Mohamed Khalifa et autres

BACKGROUND: The evidence on the efficacy and safety of sirolimus therapy in patients with low-flow vascular malformations (LFVMs) has indicated its potential benefit in extensive and complicated lesions. This study aimed to assess the efficacy and safety of oral sirolimus therapy on …

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In vitro characterisation of the patient-specific haemodynamics of an extracranial peripheral arteriovenous malformation using PIV

Aloma Blanch-Granada, Theofilos Boulafentis, Chung Sim Lim, Janice C S Tsui et autres

Peripheral Arteriovenous Malformations (pAVMs) are congenital vascular anomalies characterised by abnormal connections between arteries and veins that bypass the capillary network. This bypass results on a high-flow and low resistance vascular structure termed nidus. The high-flow and complex angioarchitecture of pAVMs makes …

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Towards Sensitivity Analysis: 3D Venous Modelling in the Lower Limb

Magdalena Otta, Karol Zając, Maciej Malawski, Ian Halliday et autres

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MA12.07 Amivantamab Plus Lazertinib vs Osimertinib in First-Line, EGFR-Mutant Advanced NSCLC: Patient-relevant Outcomes from MARIPOSA

Danny Nguyen, B. Besse, B.C. Cho, S.-H. Lee et autres

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526 Clinical Efficacy and Safety of Oral Sirolimus Therapy in Patients with Klippel-Trenaunay Syndrome in a Single Specialist Centre

Rebecca Nisbet, Calver Pang, Nicholas Evans, Anthie M. Papadopoulou et autres

Abstract Aim The evidence on the efficacy and safety of sirolimus therapy in patients with Klippel-Trenaunay Syndrome (KTS) remained scarce. This study aimed to assess this for patients for whom standard treatment alone was inadequate. Method This was a retrospective study of …

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Transfontanellar shear wave elastography of the neonatal brain for quantitative evaluation of white matter damage

Flora Faure, Marianne Alison, Mariantonietta Francavilla, Priscilla Boizeau et autres

Abstract Cerebral white matter damage (WMD) is the most frequent brain lesion observed in infants surviving premature birth. Qualitative B-mode cranial ultrasound (cUS) is widely used to assess brain integrity at bedside. Its limitations include lower discriminatory power to predict long-term outcomes …

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Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury

Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier et autres

Preterm birth is associated with cerebrovascular development disruption and can induce white matter injuries (WMI). Transfontanellar ultrasound Doppler is the most widely used clinical imaging technique to monitor neonatal cerebral vascularisation and haemodynamics based on vascular indexes such as the resistivity index …

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