Amelie Fritz

Contrastive omics pre-training for multimodal embeddings of genomic sequences

Lyam Baudry, Cyril Matthey-Doret, Amelie Fritz, Celia Ramondi

ch, dk, gb (code pays fourni par la source)

Contrastive omics pre-training for multimodal embeddings of genomic sequences

Lyam Baudry, Cyril Matthey-Doret, Amelie Fritz, Celia Ramondi

The exponential growth of genomic data presents a significant challenge in bridging the gap between raw DNA sequences and their complex biological functions.We introduce CLOP (Contrastive Learning for Omics Pre-training), a model designed to learn joint representations of DNA sequences and their …

ch, dk, gb (code pays fourni par la source)

Network medicine-based epistasis detection in complex diseases: ready for quantum computing

Markus Hoffmann, Julian Poschenrieder, Massimiliano Incudini, Sylvie Baier et autres

Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) (1-3). Existing statistical computational methods for EI detection are mostly limited to pairs of …

us, de, it, dk, ch, kr, pl, be, jp (code pays fourni par la source)

Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB

Anders Eliasen, Casper Pedersen, Morten Arendt Rasmussen, Ni Wang et autres

BACKGROUND: Asthma with severe exacerbation is one of the most common causes of hospitalization among young children. Exacerbations are typically triggered by respiratory infections, but the host factors causing recurrent infections and exacerbations in some children are poorly understood. As a result, …

dk, us, se (code pays fourni par la source)

Influence of network properties on a migration induced secular height trend by Monte Carlo simulation

Amelie Fritz, Angelina Makeyeva, Kaspar Staub, Detlef Groth

Background: Recent research reported height biased migration of taller individuals and a Monte Carlo simulation showed that such preferential migration of taller individuals into network hubs can induce a secular trend of height.In the simulation model taller agents in the hubs raise …

de, ch (code pays fourni par la source)