Matthew Edward Rogers

Exploiting nectar and blood feeding cues and phagostimulants to optimise Attractive Targeted Sugar Baits against a sand fly vector of leishmaniasis

Daniele Pereira Castro, Fernando Ariel Genta, Matthew Edward Rogers

BACKGROUND: Leishmaniasis presents a major public health problem for a large number of countries requiring effective integrated management of the vector, sand flies, for sustained control. Such strategies need to be economically and environmentally sustainable and adaptable to the behaviour of local …

br, gb, th (code pays fourni par la source)

Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection

Yonca Keşkek Türk, Ailish McCafferty-Brown, Liam Barningham, Magdalena Jančářová et autres

Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined. We establish a mouse model of Toscana virus (TOSV) infection that incorporates sand fly salivary factors to mimic natural transmission. Saliva …

gb, cz, tr, it (code pays fourni par la source)

Exploiting nectar and blood feeding cues and phagostimulants to optimise Attractive Targeted Sugar Baits against a sand fly vector of leishmaniasis

Daniele Pereira de Castro, Fernando Ariel Genta, Matthew Edward Rogers

Abstract Background Leishmaniasis presents a major public health problem for a large number of countries requiring effective integrated management of the vector, sand flies, for sustained control. Such strategies need to be economically and environmentally sustainable and adaptable to the behaviour of …

br, gb (code pays fourni par la source)

Gels and cells: the Leishmania biofilm as a space and place for parasite transmission

Matthew Edward Rogers, Luis Miguel De Pablos, Jack Daniel Sunter

Leishmania make an abundant glycoprotein and proteophosphoglycan-rich gel, called the promastigote secretory gel, in the anterior midgut of their sand fly vector. This gel is a multi-faceted virulence factor which promotes the survival and transmission of the parasites between hosts. Here, we …

gb, es (code pays fourni par la source)

Comparison of collection methods for Phlebotomus argentipes sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis

Shannon McIntyre-Nolan, Vijay Kumar, Miguella Mark‐Carew, Kundan Kumar et autres

BACKGROUND: The kala-azar elimination programme has resulted in a significant reduction in visceral leishmaniasis (VL) cases across the Indian Subcontinent. To detect any resurgence of transmission, a sensitive cost-effective surveillance system is required. Molecular xenomonitoring (MX), detection of pathogen DNA/RNA in vectors, …

gb, in (code pays fourni par la source)

C-reactive protein binds to short phosphoglycan repeats of Leishmania secreted proteophosphoglycans and activates complement

Eu Shen Seow, Eve C. Doran, Jan-Hendrik Schroeder, Matthew Edward Rogers et autres

Human C-reactive protein (CRP) binds to lipophosphoglycan (LPG), a virulence factor of Leishmania spp., through the repeating phosphodisaccharide region. We report here that both major components of promastigote secretory gel (PSG), the filamentous proteophosphoglycan (fPPG) and the secreted acid phosphatase (ScAP), are …

gb (code pays fourni par la source)

Temperature dependence of magnetic anisotropy and domain wall tuning in BaTiO3(111)/CoFeB multiferroics

Robbie G. Hunt, Kévin J. A. Franke, Paul Steven Keatley, Philippa M. Shepley et autres

Artificial multiferroics consist of two types of ferroic materials, typically a ferroelectric and ferromagnet, often coupled interfacially by magnetostriction induced by the lattice elongations in the ferroelectric. In BaTiO3 the magnitude of strain induced by these elongations is heavily temperature dependent, varying …

Allosteric modulation of a human odorant receptor

Casey Trimmer, Randy Arroyave, Christine Vuilleumier, Lily L. Wu et autres

Odor perception is first determined by how the myriad of environmental volatiles are detected at the periphery of the olfactory system. The combinatorial activation of dedicated odorant receptors generates enough encoding power for the discrimination of tens of thousands of odorants. Recent …

us, ch (code pays fourni par la source)

Comparison of collection methods for Phlebotomus argentipes sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis

Shannon McIntyre-Nolan, Vijay Kumar, Miguella Mark Carew, Kundan Kumar et autres

Abstract Background The kala-azar elimination programme has resulted in a significant reduction in visceral leishmaniasis (VL) cases across the Indian Subcontinent. To detect any resurgence of transmission, a sensitive cost-effective surveillance system is required. Molecular xenomonitoring (MX), detection of pathogen DNA/RNA in …

gb, in (code pays fourni par la source)

Fetal Loss and Preterm Birth Caused by Intraamniotic Haemophilus influenzae Infection, New Zealand

Thomas E. Hills, Caitlin Sharpe, Thomas K.S. Wong, Tim Cutfield et autres

Invasive Haemophilus influenzae infection during pregnancy can cause preterm birth and fetal loss, but the mechanism is unclear. We investigated 54 cases of pregnancy-associated invasive H. influenzae disease in 52 unique pregnancies in the Auckland region of New Zealand during October 1, …

nz (code pays fourni par la source)

Micro-CT visualization of a promastigote secretory gel (PSG) and parasite plug in the digestive tract of the sand fly Lutzomyia longipalpis infected with Leishmania mexicana

M. J. R. Hall, Debashis Ghosh, Daniel Martín‐Vega, Brett L. Clark et autres

Leishmaniasis is a debilitating disease of the tropics, subtropics and southern Europe caused by Leishmania parasites that are transmitted during blood feeding by phlebotomine sand flies (Diptera: Psychodidae). Using non-invasive micro-computed tomography, we were able to visualize the impact of the laboratory …

gb, bd, es (code pays fourni par la source)

Micro‐CT imaging of Onchocerca infection of Simulium damnosum s.l . blackflies and comparison of the peritrophic membrane thickness of forest and savannah flies

M. J. R. Hall, Daniel Martín‐Vega, Brett L. Clark, Debashis Ghosh et autres

Onchocerciasis is a neglected tropical disease (NTD) caused by Onchocerca Diesing 1841 (Spirurida: Onchocercidae) nematodes transmitted by blackflies. It is associated with poverty and imposes a significant health, welfare and economic burden on many tropical countries. Current methods to visualize infections within …

gb, es, bd, Ghana (code pays fourni par la source)