Trevor Wattam

Abstract 2976: XPR1 and SLC34A2 (NaPi2B)- A tale of targeting the phosphate homeostasis in cancer cells

Mansi Babbar, Dion A. Daniels, Katie Vowell, Rajesh Sundaresan et autres

Abstract SLC34A2 is overexpressed in 61% of ovarian cancer and 18% of uterine cancer tumors. SLC34A2 overexpression is believed to be driven by the aberrant activity of the essential PAX8 transcription factor in these tumors. Overexpression of SLC34A2, a phosphate importer, sensitizes …

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High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization

Peter Thomas, Chloe Rees-Spear, Sarah Griffith, Luke Muir et autres

Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion. We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immunization regimen may progressively escalate selection pressure on competing B …

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Supplementary Figure 1 and Table 1 from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Supplementary Figure 1: Testing GSK3178022 binding to human LRP6, mouse LRP6 and human LRP5 in an ELISA format. Supplmentary Table 1: Mutation data in PDX models

Supplemental Figure Legend from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Supplemental Figure Legend 1

Supplemental Figure Legend from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Supplemental Figure Legend 1

Supplementary Figure 1 and Table 1 from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Supplementary Figure 1: Testing GSK3178022 binding to human LRP6, mouse LRP6 and human LRP5 in an ELISA format. Supplmentary Table 1: Mutation data in PDX models

Data from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Abstract Aberrant WNT signaling is associated with the formation and growth of numerous human cancer types. The low-density lipoprotein receptor-related protein 6 (LRP6) is the least redundant component of the WNT receptor complex with two independent WNT ligand-binding sites. Using domain antibody …

Data from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather Jackson, David Granger, Gavin W. Jones, Louisa Anderson et autres

Abstract Aberrant WNT signaling is associated with the formation and growth of numerous human cancer types. The low-density lipoprotein receptor-related protein 6 (LRP6) is the least redundant component of the WNT receptor complex with two independent WNT ligand-binding sites. Using domain antibody …

Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients

Eleonora Lekova, Wioleta M. Zelek, David J. Gower, Claus Spitzfaden et autres

Myasthenia Gravis (MG) is mediated by autoantibodies against acetylcholine receptors that cause loss of the receptors in the neuromuscular junction. Eculizumab, a C5-inhibitor, is the only approved treatment for MG that mechanistically addresses complement-mediated loss of nicotinic acetylcholine receptors. It is an …

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‘In-Format’ screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules

M.J. Scott, Jennifer A. Lee, Matthew Wake, Kelly V. Batt et autres

Bispecific antibodies (BsAbs) are emerging as an important class of biopharmaceutical. The majority of BsAbs are created from conventional antibodies or fragments engineered into more complex configurations. A recurring challenge in their development, however, is the identification of components that are optimised …

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Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth

Heather L. Jackson, David Granger, Gavin C. Jones, Louisa Anderson et autres

UNLABELLED: Aberrant WNT signaling is associated with the formation and growth of numerous human cancer types. The low-density lipoprotein receptor-related protein 6 (LRP6) is the least redundant component of the WNT receptor complex with two independent WNT ligand-binding sites. Using domain antibody …

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Characterisation of Antibodies Against the Active Conformation of G αi1 Using the SRU‐BIND® Label‐Free Detection System

Melanie Leveridge, Chun‐wa Chung, Trevor Wattam

This chapter contains sections titled: Introduction Materials and Methods Results and Discussion Conclusions Acknowledgements References

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