Yongfei Guo

A cascade-catalytic scaffold reprograms metabolic niche to boost bone repair via enhanced mitochondrial bioenergetics and osteoimmunomodulation

Xiao Wang, Jiajie Chen, Jialin Jiang, Jimin Huang et autres

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Innovative application of the expanded shelter technique in C2-involving cervical OPLL: a case report

Bo Xu, Bing Zheng, Jin Zh, Yang Hou et autres

BACKGROUND CONTEXT: Ossification of the posterior longitudinal ligament (OPLL) involving the C2 segment poses significant surgical challenges due to anatomical complexity and limited exposure. PURPOSE: This report describes a novel application of the Expanded Shelter Technique to overcome C3-level exposure constraints in …

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Genomic characterization of SMARCA4 -mutant versus wild-type non–small cell lung cancer in a Chinese population: A large-scale next-generation sequencing study.

Tongguo Si, Mao Yang, Yongfei Guo

8547 Background: SMARCA4 is a core component of the SWI/SNF chromatin remodeling complex and plays a critical role in transcriptional regulation and tumor suppression. SMARCA4 mutations define a biologically aggressive subset of lung cancer; however, their genomic landscape and clinical implications in …

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Targeting mitochondrial oxidative stress: A novel therapeutic strategy for degenerative joint diseases (Review)

Yang Hou, Xiaolei Yang, Tianyi Zhao, Yongfei Guo et autres

Degenerative joint diseases, such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA), cause pain and disability worldwide. Globally, OA affects >500 million individuals, IVDD affects 40-60% of adults and RA affects 0.5-1% of the global population. Current treatments (such …

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Unveiling the role of lumbar intervertebral space morphology: a novel classification and its impact on cage migration in lumbar fusion surgery

Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo et autres

PURPOSE: This study aimed to establish a novel classification system for lumbar intervertebral spaces based on anatomical morphology, to investigate the relationship between intervertebral space types and cage migration risk after transforaminal lumbar interbody fusion (TLIF), and to optimize fusion strategies tailored …

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Based on the mechanism of degeneration of the small joint – muscle – intervertebral disc complex and early intervention

Shunmin Wang, Xiaoming Guo, Lina Liu, Jiangang Shi et autres

Background: Emerging evidence suggests that facet joint degeneration, disc pathology, and paraspinal muscle atrophy form a degenerative triad in young adults with lumbar disc herniation (LDH). However, the exact relationship remains unknown. This study aimed quantitatively to investigate their interrelationships through magnetic …

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Predicting bone metastasis and high-grade Gleason scores in prostate cancer: a retrospective study integrating clinical features and magnetic resonance imaging radiomics

Yuling Yang, Bin Zou, Bowen Zheng, Yongfei Guo et autres

Background: Prostate cancer (PCa) is a common malignant tumor in older men, and bone metastasis is its most frequent form. Once bone metastasis occurs, survival drops sharply. The Gleason score is the standard tool for judging how aggressive the cancer is; men …

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The multifaceted role of SQSTM1/p62 in disc degeneration: A master regulator of cellular stress responses

Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo et autres

Intervertebral disc degeneration (IDD) is a key contributor to lumbar degenerative diseases and chronic low back pain. Accumulating evidence indicates that Sequestosome 1 (SQSTM1/p62), a multifunctional adaptor protein, plays a pivotal role in IDD pathogenesis through its regulation of autophagy, oxidative stress, …

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Macrophage reprogramming as a therapeutic avenue in intervertebral disc degeneration: Insights into pharmacological targeting

Yang Hou, Tianyi Zhao, Yongfei Guo, Jiangang Shi

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[Correlation between neutrophil extracellular traps and clinicopathological characteristics and prognosis of EGFR wild-type lung adenocarcinoma].

Xiandi Zhang, Renjian Zhang, Yongfei Guo, Liwei Wu et autres

The EGFR wild-type lung adenocarcinoma patients with high expression of NETs have relatively shorter DFS and OS, which are independent risk factors for the prognosis of patients with EGFR wild-type lung adenocarcinoma, and are likely to be the potential biomarkers for the …

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MRI Radiomics and Automated Habitat Analysis Enhance Machine Learning Prediction of Bone Metastasis and High-Grade Gleason Scores in Prostate Cancer

Yuling Yang, Bowen Zheng, Bin Zou, Renyi Liu et autres

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The coexistence of crowned dens sign and calcification of ligamentum flavum in the cervical spine: mere coincidence or meaningful association?

Yake Meng, Lili Zhou, Rongxue Shao, Wei Zhang et autres

We present a case series of cervical radiculomyelopathy caused by calcification of the ligamentum flavum (CLF), with or without concomitant periodontoid calcification. A brief literature review is presented, highlighting a potential relationship between these 2 conditions. In this retrospective study, we reviewed …

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