Marcel den Dulk

Prognostic host phenotypes based on body composition and systemic inflammation predict survival in patients with resected pancreatic and periampullary cancer

Nicole D Hildebrand, David P.J. van Dijk, Jisce R. Puik, Anne Claire Henry et autres

INTRODUCTION: Most present-day survival-models of patients with cancer do not account for tumor-host interactions. We hypothesized that host phenotypes based on systemic inflammation and body composition are prognostic of overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: We performed …

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Surgical outcomes from nationwide implementation of the international best practice for locally advanced pancreatic cancer (PREOPANC-4) study

Thomas F. Stoop, Leonard W F Seelen, Freek R. van ‘t Land, Jacobien C M Scheepens et autres

BACKGROUND: In expert centres, surgical resection rates for patients with locally advanced pancreatic cancer (LAPC) after induction chemotherapy have increased beyond 20% with subsequent 25% 5-year overall survival (OS). In the Netherlands, however, the historical low 8% LAPC resection rate compared with …

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Contemporary challenges in long-term survival prediction in resected pancreatic ductal adenocarcinoma: a transatlantic multicenter development and validation of prognostic models

Ammar A. Javed, Mahsoem Ali, Omar Mahmud, Fabio Casciani et autres

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Hepatobiliary surgical training in a changing educational landscape: An 18-year longitudinal analysis of a high-volume international fellowship programme

Dániel Wettstein, Florian Primavesi, Omar Alkhatib, Aurélien Dupré et autres

BACKGROUND: Hepatobiliary (HB) surgery is increasingly complex, requiring expertise beyond general surgery training. Structured fellowship programmes aim to ensure adequate operative training, academic growth, and global leadership, but their outcomes are not well studied. The Liverpool Hepatobiliary Fellowship has provided international HB …

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Long-term outcome after liver surgery for colorectal metastases in elderly patients: a nationwide population-based study

Victor van Woerden, Michelle R. de Graaff, Arthur K.E. Elfrink, Dirk J. Grünhagen et autres

BACKGROUND: Age alone is no longer a contraindication for resection of colorectal liver metastases (CRLM). The aim of this study was to compare survival after resection of CRLM across different age groups. METHODS: A population-based study of patients who underwent resection of …

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Patient-recorded indexing measurements (PRIMS) – study protocol of a prospective observational cohort study to improve the accuracy of the diagnosis of cancer cachexia

Nicole D Hildebrand, Misha A. T. Sier, Sander M. J. van Kuijk, Lianne Hoeijmakers et autres

BACKGROUND: Cachexia is a major challenge throughout cancer treatment. Unintentional weight loss, the principal diagnostic criterium of cancer cachexia, is usually assessed through self-reported body weight change, which may be prone to bias. Other aspects of cancer cachexia include altered body composition …

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The effectiveness of adding Braun anastomosis to standard Child reconstruction to reduce delayed gastric emptying after pancreatoduodenectomy (REMBRANDT): study protocol for a multicentre randomised-controlled trial

Bo T M Strijbos, Jana S. Hopstaken, C Endo, Marjan de Vries et autres

BACKGROUND: Pancreatoduodenectomy (PD) is associated with a high risk of complications, such as delayed gastric emptying (DGE) (19-45%). Patients with DGE experience symptoms of nausea, vomiting, inability to tolerate solid food and prolonged dependence on a nasogastric tube (> 7 days), leading …

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Response to comment on “The usefulness of the modified steep ramp test as a practical exercise test for preoperative risk assessment in patients scheduled for pancreatic surgery”

Heleen Driessens, Marcel den Dulk, Steven W.M. Olde Damink, Joost M. Klaase et autres

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Short- and long-term outcomes after venous resection during left-sided and total pancreatic resection: a nationwide cohort study

Nynke Michiels, Jenny Fk Tromp, Daan J. Comes, Jesse V. Groen et autres

BACKGROUND: Venous resection (VR) during left-sided pancreatic resection (LPR) is typically more challenging than during pancreatoduodenectomy, because the pancreatic head remains in situ. Theoretically, converting from LPR to total pancreatectomy (TP) could resolve this issue. This study compared clinical outcomes after LPR …

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Selection for local treatment and outcomes of surgical resection in patients with synchronous colorectal liver metastases: A nationwide population-based study

Michelle R. de Graaff, Joost M. Klaase, Marcel den Dulk, Dirk J. Grünhagen et autres

BACKGROUND: The aim of this study was to evaluate potential disparities in the probability of undergoing surgical treatment among patients with synchronous colorectal liver metastases (CRLM) and to investigate which non-tumour-related characteristics influenced postoperative outcomes. METHODS: This was a population-based study of …

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Prehabilitation before pancreatic surgery in the Netherlands: insights from a nationwide survey among pancreatic surgeons

Heleen Driessens, Carlijn I. Buis, Steven W.M. Olde Damink, Joost M. Klaase et autres

BACKGROUND: Prehabilitation programs are increasingly used to optimize patients before pancreatic surgery. A prehabilitation program should include screening, assessment, intervention, and reassessment of multiple patient-related modifiable risk factors. Consensus on the content of a prehabilitation program and which patients should receive prehabilitation …

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Time-varying impact of established prognostic factors in resected pancreatic ductal adenocarcinoma

Ammar A. Javed, Asad Saulat Fatimi, Ingmar F. Rompen, Omar Mahmud et autres

BACKGROUND: Prognostic factors in resected pancreatic ductal adenocarcinoma (PDAC) have been determined under the assumption that hazard ratios (HRs) remain static. However, PDAC is a dynamic disease with evolving conditional survival. The aim of this study was to determine if the impact …

us, nl, Tanzanie, de (code pays fourni par la source)