Olivier Fardel

Report of the scientific network Holimitox on succinate dehydrogenase inhibitor (SDHI) pesticides: new insights and challenges with an EcoHealth approach—presentations and round tables from the Holimitox day on November 7, 2024

Jean‐Marc Bonmatin, François Chamaraux, Séverine Jean, Emmanuella Abbey et autres

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In vitro prediction of the immunogenicity of therapeutic proteins: state of the art and current challenges and perspectives

Olivier Fardel, Emna Mahfoudhi, Laurence Launay, Amélie Moreau et autres

Introduction Immunogenicity of therapeutic proteins is a major concern because it may compromise their clinical use and efficacy. Preclinical prediction of anti-drug antibody development using in vitro assays is therefore a challenge for candidate biologics.Areas covered This review, based on a thorough …

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Inhibition of human organic anion transporter 4 (OAT4) activity by bisphenol analogues

Hélène Le Mentec, David Malnoë, Marc Le Vée, Olivier Fardel

Organic anion transporter (OAT) 4 is a kidney and placental membrane protein implicated in the transport of xenobiotics, including pollutants. The present study was designed to determine whether environmental bisphenol (BP) analogues, including emerging bisphenol A substitutes, can interact with OAT4. 6-carboxyfluorescein-related …

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Correction: Karoui et al. Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction. Int. J. Environ. Res. Public Health 2020, 17, 5526

Ahmed Karoui, Clément Crochemore, Najah Harouki, Cécile Corbière et autres

In the original publication [...].

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Repression of bile salt efflux pump expression by tri-ortho-cresyl phosphate in cultured human hepatic cells

Valentin Tastet, Marc Le Vée, Jennifer Carteret, David Malnoë et autres

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Human liver cell-based assays for the prediction of hepatic bile acid efflux transporter inhibition by drugs

Olivier Fardel, Amelie Carla Moreau, Elodie Jouan, Claire Denizot et autres

INTRODUCTION: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is therefore a major issue, which can be addressed using liver cell-based assays. …

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Induction of drug metabolizing enzyme and drug transporter expression by antifungal triazole pesticides in human HepaSH hepatocytes

Anna Zerdoug, Marc Le Vée, Hélène Le Mentec, Jennifer Carteret et autres

Triazole pesticides are widely used fungicides, to which humans are rather highly exposed. They are known to activate drug-sensing receptors regulating expression of hepatic drug metabolizing enzymes and drug transporters, thus suggesting that the hepatic drug detoxification system is modified by these …

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Lack of effects of polystyrene micro- and nanoplastics on activity and expression of human drug transporters

Valentin Tastet, Marc Le Vée, Alexis Verger, Nolwenn Brandhonneur et autres

Micro- and nanoplastics (MPs/NPs) constitute emerging and widely-distributed environmental contaminants to which humans are highly exposed. They possibly represent a threat for human health. In order to identify cellular/molecular targets for these plastic particles, we have analysed the effects of exposure to …

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P12-17 Differential effects of triazole pesticides on phase I CYP P450 enzymes in the human hepatocytes HepaSH™

P. El Azzi, Anna Zerdoug, Agnès Jamin, Nathan Stockman et autres

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The Competitive Counterflow Assay for Identifying Drugs Transported by Solute Carriers: Principle, Applications, Challenges/Limits, and Perspectives

Olivier Fardel, Amelie Carla Moreau, Jennifer Carteret, Claire Denizot et autres

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Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors

Marie Kerhoas, Marc Le Vée, Jennifer Carteret, Elodie Jouan et autres

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Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors

Marie Kerhoas, Jennifer Carteret, Lilou Huchet, Elodie Jouan et autres

Succinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these agrochemicals, the interactions of 15 SDHIs with expression and activity of human …

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