Chelsea Ye

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …

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Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

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Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

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Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

Janie F. Shelton, Anjali J. Shastri, Chelsea Ye, Catherine H. Weldon et autres

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Trans-ethnic analysis reveals genetic and non-genetic associations with COVID-19 susceptibility and severity

Janie F. Shelton, Anjali J. Shastri, Chelsea Ye, Catherine H. Weldon et autres

Abstract COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of over one million 23andMe research participants, we report genetic and non-genetic associations with testing positive for COVID-19, respiratory symptoms, …

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