Alexander J. George

High density lipoprotein particle size and function associate with new cardiovascular events in patients with chronic kidney disease

Anna Vachaparampil Mathew, Yun Jae Han, Vetalise C Konje, Yanhong Guo et autres

Chronic Kidney Disease (CKD) is a risk factor for cardiovascular disease (CVD), and patients with CKD have markedly higher CVD mortality compared to healthy controls. However, the relationship between specific lipoprotein profiles and new CV events in patients with advanced CKD and …

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The Curious Case of a Pilonidal Sinus of the Sole of the Foot Mimicking a Painful Corn: An Unusual Entity

Alexander J. George

The term “pilonidal sinus,” first described by Herbert Mayo in 1833, and later named “pilonidal sinus” by Hodges in 1880, brings to our mind the ever-suffering patient with a discharging, painful, and nonhealing lesion in the sacrococcygeal area.[ 1 ] However, a …

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P0264 Using a machine learning model to grade clip-level endoscopic inflammation reveals the heterogeneity of mucosal inflammation in ulcerative colitis

Alexander J. George, Klaus T. Gottlieb, Shrujal S. Baxi, William Eastman et autres

Abstract Background Endoscopic assessment of inflammation in ulcerative colitis (UC) is a therapeutic endpoint in clinical trials1 but can be limited by inter- and intra-observer variability2 and lack of sensitivity to detect the degree of inflammation throughout the colon3. We used a …

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P0451 Using a machine learning model to assess agreement between inflammation in the rectosigmoid and entire colon in patients with ulcerative colitis

Alexander J. George, Klaus T. Gottlieb, Shrujal S. Baxi, William Eastman et autres

Abstract Background Limited endoscopy of the rectosigmoid colon is sometimes used to assess endpoints in clinical trials for ulcerative colitis (UC). However, there is inherent inter- and intra-rater variability in endoscopic assessment of inflammation, and regulatory agencies have suggested that full colonoscopy …

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Congenital agenesis of the right pulmonary artery

Alexander J. George

Post-Partum Spontaneous Coronary Artery Dissection with Occluded Left Anterior Descending Artery.

T Davies, Jingzhou He, A Hawley, Barbara Dyer et autres

Presentation We present a case of spontaneous coronary artery dissection (SCAD) in a 35-year-old lady who was 4 months post-partum. Despite a lack of typical risk factors, initial presentation and investigations were strongly suggestive of ACS. Diagnosis Coronary angiography revealed an occluded …

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Pituitary apoplexy and panhypopituitarism following acute leptospirosis

Jaypalsinh A. Gohil, Arun Gowda, Tobin George, Hariharan Venkat Easwer et autres

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Patient reported outcomes in prospective cohort study of Electrochemotherapy

Nada Al‐Hadithy, Alexandra Dehnel, Alexander J. George, Robert Kisiel et autres

Metastatic spread of malignant tumours to skin is a well described phenomenon with incidence of approximately 0.7-9% of all metastases depending on histological type of primary cancer. Electrochemotherapy (ECT) is an efficient local tumour ablation modality that has proven clinical efficacy in …

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Management of Nail Bed Injuries Associated with Fingertip Injuries

Alexander J. George, Reena Alexander, C Manju

Management of nail injuries can often be a challenging experience, especially in presence of complex fingertips’ injuries that include soft tissue loss and distal phalanx injury. Most studies found in the literature focus on individual injuries and describe methods to tackle those …

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Reexpression of Prior Stroke Symptoms in Adults

James Ernest Siegler, Alexander J. George, Sheryl Martin‐Schild

A "stroke mimic" refers to any clinical condition that causes neurological symptoms clinically indistinguishable from a cerebral lesion that affects a vascular distribution, but is not caused by ischemia. One subtype of stroke mimic, termed stroke reexpression, is a form of mimicry …

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Factor VIII Level is Not Modifiable by Improved Glycemic Control in Patients with Ischemic Stroke.

Alyana A. Samai, Amelia K. Boehme, Alexander J. George, Laurie Schluter et autres

AIMS: To determine whether the degree of glycemic control was related to change in Factor VIII (FVIII) level in patients with acute ischemic stroke (AIS). METHODS: From our stroke registry, all AIS patients admitted between 07/2008-05/2014 with baseline HbA1c and FVIII levels …

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The role of a history of coronary artery disease, the need for transfusion and outcomes in patients with intracerebral hemorrhage (P2.264)

Ayaz Mahmood Khawaja, Amelia K. Boehme, Alexander J. George, Angela Hays Shapshak et autres

To investigate the relationship between transfusion and outcomes in primary-ICH patients with and without CAD.

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