Aime T. Franco

Hras G12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to Kras G12D

Nicholas E. Bambach, Katherine Labella, Lee Ann Jolly, Diana Isabel Cruz et autres

Abstract RAS mutations are found in nearly 50% of follicular thyroid cancers (FTCs), frequently accompanied by secondary mutations in the PI3K/AKT pathway as tumors advance to more poorly differentiated states. To examine the role that oncogenic Hras plays in thyroid tumor initiation …

us (code pays fourni par la source)

The landscape of paediatric differentiated thyroid carcinoma and predictors of invasive disease: a CATC study

Wasserman JD, Isaza AR, Waguespack SG, Ari J. Wassner et autres

GATES: A Lightweight Tool Automating Pathogenic Variant Discovery From Raw Whole-Exome Sequencing Data

Nicholas E. Bambach, Julio C. Ricarte‐Filho, Erin R. Reichenberger, Aime T. Franco

Background Whole-exome sequencing is a widely used technology to identify pathogenic variants in cancer. Although sequencing itself has become increasingly accessible, downstream analysis remains computationally complex, presenting a challenge for many researchers. Existing pipelines lack integrated support for somatic and germline variant …

us (code pays fourni par la source)

Distinct molecular profiles of indeterminate and malignant thyroid nodules in patients under 21 years of age

Julio C. Ricarte‐Filho, Luz Castellanos, Steven G. Waguespack, Julian Bryan et autres

Although uncommon, thyroid nodules (TNs) in pediatric and young adult patients carry a higher malignancy risk and often present with a high burden of metastatic disease than in adults. The molecular features underlying this distinct clinical behavior remain unclear. We analyzed Afirma …

us (code pays fourni par la source)

Supplementary Table S1 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

Summary of Tissue type, Invasiveness, Driver Mutation, Histology, Sex and TNM Staging in The Reference and Validation Cohort.

Supplementary Figure S4 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

Construction of models for pediatric thyroid carcinoma invasiveness.

Supplementary Figure S2 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

Analysis of methylation and transcriptional patterns in thyroid carcinoma clusters.

Supplementary Table S3 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

Representativeness of Study Participants

Supplementary Table S2 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

Summary of Model Performance on Pediatric Thyroid Cancer Sample Cases

Data from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

AbstractPurpose: Accurate assessment of invasiveness in pediatric thyroid carcinomas is essential to prevent unnecessary surgery and avoid surgery-associated complications. DNA methylation, a proven molecular biomarker for cancer classification, holds promise for stratifying thyroid cancer risk. The objectives were to determine the epigenetic …

Supplementary Table S4 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

TCGA Adult Thyroid Cancer Cases Studied.

Supplementary Figure S1 from DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma

Jenny Z. Li, Julio C. Ricarte‐Filho, Amber R. Isaza, Kyle Hinkle et autres

DNA methylation reveals distinct subgroups of pediatric thyroid carcinoma