Accès ouvert
2025
preprint
OpenAlex
Grace Marden, Kimberly P. Schmitt, Maxwell I. Zimmerman, Alex H. Ramos et autres
SUMMARY Sarbecoviruses, a subgenus of coronaviruses, include strains with zoonotic spillover risk as exemplified by recent outbreaks (SARS-CoV-1, SARS-CoV-2). Monoclonal antibodies targeting conserved spike protein regions (RBD class 4, S2 fusion machinery) exhibit broad sarbecovirus neutralization, but their utility has been impacted …
us
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Accès ouvert
2025
article
OpenAlex
Kimberly P. Schmitt, Grace Marden, Eric Carlin, Álex Ramos et autres
Abstract Background The elderly and immunocompromised remain at high risk of severe COVID-19 due to suboptimal immune responses. Monoclonal antibodies to SARS-CoV-2 spike were highly effective for both prophylaxis and treatment, but quickly became ineffective due to viral escape. Using a machine …
us
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Accès ouvert
2024
article
OpenAlex
Takashi Yamashita, Ulas Kaplan, Adri Chakraborty, Grace Marden et autres
OBJECTIVE: Rarefaction of blood and lymphatic vessels in the skin has been reported in systemic sclerosis (SSc) (scleroderma). E26 transformation-specific-related factor (ERG) and Friend leukemia virus-induced erythroleukemia 1 (FLI-1) are important regulators of angiogenesis, but their role in lymphatic vasculature is lesser …
us, jp
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Accès ouvert
2023
article
OpenAlex
Francesco Borriello, Grace Marden, Hongru Li, Eric Carlin et autres
Abstract Background The clinical benefit of anti-spike mAbs for prophylaxis and treatment of SARS-CoV-2 is now well established (Baum 2020, Loo 2022, Westendorf 2022, Jones 2021, Kreuzberger 2021, Cathcart 2021, Hirsch 2022, Shi 2020); However, the evolution of SARS CoV-2 due to …
us
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Accès ouvert
2023
article
OpenAlex
Tetsuo Toyama, Tatiana V. Kudryashova, 市原 麻子, Stefania Lenna et autres
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcription factor GATA6 is a shared pathological feature of PA endothelial …
us
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Accès ouvert
2022
erratum
OpenAlex
Nunzia Caporarello, Jisu Lee, Tho Xuan Pham, Dakota L. Jones et autres
The original version of this article contained errors in Figure 3d–f and Figure 4f–h, in which the scale bars were white, instead of colored. These errors have been corrected in the PDF and HTML version of the article.
us
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Accès ouvert
2022
article
OpenAlex
Nunzia Caporarello, Jisu Lee, Tho Xuan Pham, Dakota L. Jones et autres
Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the vasculature to lung repair and fibrosis is not fully understood. Here, we performed an epigenetic and transcriptional analysis of lung endothelial cells (ECs) from young and aged mice …
us
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Accès ouvert
2021
conference-abstract
OpenAlex
Nunzia Caporarello, Tho Xuan Pham, Jeffrey D. Lee, Jiahui Guan et autres
Rationale: Idiopathic Pulmonary Fibrosis (IPF) is a disease of aging with limited therapeutic options. Despite IPF lungs feature vascular abnormalities, including capillary rarefaction and vascular leak, the impact of endothelial dysfunction in the progression of this disease remains largely unexplored. We discovered …
us
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Accès ouvert
2020
article
OpenAlex
Celestina Mazzotta, Grace Marden, Giuseppina Alessandra Farina, Andreea M. Bujor et autres
OBJECTIVES: Friend leukemia integration 1 and erythroblast transformation-specific, important regulators of endothelial cell homeostasis, are reduced in microvascular endothelial cells in scleroderma patients, and their deficiency has been implicated in disease pathogenesis. The goal of this study was to identify the mechanisms …
us
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Accès ouvert
2020
article
OpenAlex
Grace Marden, Qi Wan, Jonathan A. Wilks, Katherine Nevin et autres
Abstract Background Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a significant player …
us, cn, gb
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Accès ouvert
2020
preprint
OpenAlex
Grace Marden, Qianqian Wan, James Wilks, Katherine Nevin et autres
Abstract Background: Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a significant player …
us, nl
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Andreea M. Bujor, Fatima El-Adili, Arshi Parvez, Grace Marden et autres
Scleroderma is an autoimmune connective tissue disease characterized by immune dysregulation, vasculopathy and fibrosis. We have previously demonstrated that low Fli1 expression in scleroderma fibroblasts and endothelial cells plays an important role in SSc pathogenesis. Cells of myeloid and lymphoid origin also …
us
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