Sachiko Homma

In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia

Haixia Zhou, Lea Terbeck, Andrew Berical, Marine Brunet et autres

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging to human multiciliated epithelial cells. This approach resolved TZ-specific doublet …

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FAP-derived CCL2 is required for adequate monocyte/macrophage infiltration to support acute skeletal muscle injury repair

Xingyu Wang, Yinhang Wang, Ruoxi Yuan, Gregory R. Smith et autres

, the CCL2 expression by both mouse and human FAPs was induced by danger signal-containing muscle homogenates through Toll-like receptor signaling. The CCL2 expression by mouse FAPs was also induced by infiltrating neutrophils, partly through their secretion of pro-inflammatory cytokines. Our findings …

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A stem cell-based platform for functional analysis of genetic variants in lung disease

Daniel Wallman, Sachiko Homma, M.L Beermann, Asha I. Jacob et autres

Abstract Advances in genetic and transcriptomic technologies have identified large numbers of genes and variants of potential importance to human disease. Determining the function of these genes and variants is a critical bottleneck in understanding disease etiology. Variants of uncertain significance (VUS) …

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Expansion and pathogenic activation of skeletal muscle–resident macrophages in mdx 5cv /Ccr2 −/− mice

Yinhang Wang, Xingyu Wang, Salam AlAbdullatif, Sachiko Homma et autres

Infiltrating macrophages contribute to muscle dystrophic changes in Duchenne muscular dystrophy (DMD). In a DMD mouse model, mdx 5cv mice, CC chemokine receptor type 2 (CCR2) deficiency diminishes Ly6C hi macrophage infiltration by blocking blood Ly6C hi inflammatory monocyte recruitment. This is …

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Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression

Sachiko Homma, Xingyu Wang, Justin J. Frere, Adam C. Gower et autres

Muscle fatigue represents the most prevalent symptom of long-term COVID, with elusive pathogenic mechanisms. We performed a longitudinal study to characterize histopathological and transcriptional changes in skeletal muscle in a hamster model of respiratory SARS-CoV-2 infection and compared them with influenza A …

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Supplementary Figure 1 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 1 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 4 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 4 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 1 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 1 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 4 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 4 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 3 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 3 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

Masahiro Iwasaki, Sachiko Homma, Akinori Hishiya, Samuel J. Dolezal et autres

Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells