Charles F. Reynolds

Strategies to Promote Resilience and Community Reintegration for Patients With New Disabilities After Critical Illness: A Qualitative Study Integrating Patient and Family Perspectives

Leslie Page Scheunemann, E. Motter, S. Peter Kim, Peter Eisenhauer et autres

OBJECTIVE: Millions of people who survive critical illness each year experience new disabilities that prevent them from returning to personally meaningful participation in family and community life ("community reintegration"), which is closely intertwined with resilience. We sought to describe strategies for promoting …

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Association Between Venlafaxine Exposure And Treatment Outcomes In Older Adults With Depression: Association entre l’exposition à la venlafaxine et les résultats du traitement chez les personnes âgées atteintes de dépression

Xiaoyu Men, Zachary L. Taylor, Victoria S. Marshe, Daniel M. Blumberger et autres

Background Venlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine, its active metabolite O-desmethylvenlafaxine (ODV) and its active moiety (i.e., venlafaxine …

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D25-22 Post-intensive Care—Transitional Care, Rehabilitation, and Family Support (pic-trfs): A Theory-driven Model of Community Reintegration After Critical Illness

Leslie Page Scheunemann, E R Skidmore, H A S Donovan, J J Christensen et autres

Abstract Rationale Theories of change (De Silva, 2014) explain how and why desired outcomes are expected to occur within a particular context, while intervention models operationalize those theories into concrete processes for achieving change. We sought to develop a theory of change …

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Toward Precision Psychiatry

Helena K. Kim, Xiaoyu Men, Samar S. M. Elsheikh, Daniel J. Müller et autres

PURPOSE: Decision trees can use clinical predictors to determine whether to continue the same antidepressant or switch to a different treatment in older patients with major depressive disorder (MDD). We examined whether pharmacogenetic and pharmacokinetic variables could improve their performance. PROCEDURES: We …

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Identifying clinician-reported medication “Failure modes” in the nursing home setting that are amenable to active monitoring

Chenyu Li, Olga Kravchenko, Eric Chieh‐Lung Chou, Stevem M. Handler et autres

OBJECTIVES: Nursing home residents are at high-risk for preventable harm and medication errors. This study aimed to identify clinician-reported medication safety failure modes in U.S. nursing homes and prioritize those most suitable for informatics-enabled active monitoring interventions. METHODS: We conducted a mixed-methods …

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Interventions for Bereavement

Charles F. Reynolds, Holly Gwen Prigerson, M. Katherine Shear, Sidney Zisook

This Viewpoint explores the effectiveness of various interventions for individuals experiencing grief disorders, particularly prolonged grief disorder, following the death of a loved one.

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Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression

Gyujoon Hwang, Nutta-on P. Blair, Stacy A. Claesges, Charles F. Reynolds et autres

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Risk Factors for Falls in Older Depressed Adults Treated with Bupropion: An Analysis of the OPTIMUM Randomized Clinical Trial

David Andrew Bender, Benoit H. Mulsant, Helen Lavretsky, Patrick J. Brown et autres

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Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions

Joseph S. Goveas, Gyujoon Hwang, Nutta-on P. Blair, Elliot A. Stein et autres

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Emotion regulation in prolonged grief disorder in later life: Protocol and rationale for a longitudinal neuroimaging study

Gyujoon Hwang, Nutta-on P. Blair, Volkan Emre Arpinar, B. Douglas Ward et autres

Bereavement is a near-universal experience in late life, yet only some older adults develop prolonged grief disorder (PGD). While most transition from acute grief (AG) to integrated (adaptive) grief, the neurobiological substrates underlying divergent trajectories are unclear. Emotion regulation dysfunction is hypothesized …

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Iyengar yoga and health education interventions for prolonged grief disorder in later life: feasibility of a randomized controlled pilot trial

Joseph S. Goveas, Gyujoon Hwang, T McAuliffe, Nuttaon P. Blair et autres

Mind body therapies, particularly yoga, may offer a simple, scalable, and effective intervention for prolonged grief disorder (PGD) in older adults. This pilot randomized controlled trial (RCT) compared Iyengar Yoga (IY) with Health Education (HE), an active control, assessing feasibility, safety, and …

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Hippocampal subfield volumes associated with depression symptoms in older dementia caregivers

Tales Santini, Howard Jay Aizenstein, Charles F. Reynolds, Sara Albert et autres

OBJECTIVES: Hippocampal volume reductions are associated with Major Depressive Disorder. Evidence of relationships between hippocampal subfield volumes and specific subsyndromal depression symptoms can add to our understanding of this mechanistic correlate. DESIGN: Cross-sectional correlational study. SETTING: University of Pittsburgh research facilities using …

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