Gustavo A. Niño‐Vega

Evolutionary History and Distribution Analysis of Rhamnosyltransferases in the Fungal Kingdom

Joaquín O. Chávez-Santiago, Luz A. López-Ramírez, Luis A. Pérez-García, Iván Martínez-Duncker et autres

Rhamnose is a natural sugar found in glycoproteins and structural polysaccharides of plants, fungi, and bacteria. Its incorporation into glycoconjugates is mediated by rhamnosyltransferases (RHTs), key enzymes for biomolecular stability and function. While rhamnose biosynthesis has been studied in certain fungal genera, …

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Evolutionary History and Distribution Analysis of Rhamnosyltransferases in the Fungal Kingdom

Joaquín Omar Chávez-Santiago, Luz A. López-Ramírez, Luis A. Pérez-García, Iván Martínez-Duncker et autres

Rhamnose is a natural sugar found in glycoproteins and structural polysaccharides of plants, fungi, and bacteria. Its incorporation into glycoconjugates is mediated by rhamnosyltransferases (RHTs), key enzymes for biomolecular stability and function. While rhamnose biosynthesis has been studied in certain fungal genera, …

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Novel Antibacterial Approaches and Therapeutic Strategies

Gustavo A. Niño‐Vega, Jorge A. Ortiz-Ramírez, Everardo López-Romero

The increase in multidrug-resistant organisms worldwide is a major public health threat driven by antibiotic overuse, horizontal gene transfer (HGT), environmental drivers, and deficient infection control in hospitals. In this article, we discuss these factors and summarize the new drugs and treatment …

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Novel Antibacterial Approaches and Therapeutic Strategies

Gustavo A. Niño‐Vega, Jorge A. Ortiz-Ramírez, Everardo López-Romero

The increase of multi-drug resistant organisms worldwide is a major public health threat driven by antibiotic overuse, horizontal gene transfer (HGT), environmental drivers, and deficient infection control in hospitals. In this article, we discuss these factors and summarize the new drugs and …

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Sporothrix brasiliensis Gp70 is a cell wall protein required for adhesion, proper interaction with innate immune cells, and virulence

Leonardo Padró-Villegas, Manuela Gómez-Gaviria, Iván Martínez-Duncker, Luz A. López-Ramírez et autres

that contributes to virulence and proper interaction with innate immnune cells.

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New Ground in Antifungal Discovery and Therapy for Invasive Fungal Infections: Innovations, Challenges, and Future Directions

Gustavo A. Niño‐Vega, Leonardo Padró-Villegas, Everardo López-Romero

This review explores current advancements and challenges in antifungal therapies amid rising fungal infections, particularly in immunocompromised patients. We detail the limitations of existing antifungal classes—azoles, echinocandins, polyenes, and flucytosine—in managing systemic infections and the urgent need for alternative solutions. With the …

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Análisis de expresión de genes de beta-glucanasas en el hongo patógeno Sporothrix schenckii

Guadalupe Franyutti Castillo, Paola García Negrete, Luis A. Madrigal Cerda, Alondra Martínez Ajo et autres

La pared celular es vital para la supervivencia de las células fúngicas y sus componentes estructurales, esenciales para la integridad del hongo, no están presentes en el hospedero humano. Esto convierte a los mecanismos de síntesis de la pared celular en un …

The Heat Shock Protein 60 and Pap1 Participate in the Sporothrix schenckii-Host Interaction

Laura Cristina García-Carnero, Roberta Salinas-Marín, Nancy E. Lozoya‐Pérez, Katarzyna Wróbel et autres

Sporothrixschenckii is one of the etiological agents of sporotrichosis, a worldwide-distributed subcutaneous mycosis. Its cell wall contains a glycoconjugate composed of rhamnose, mannose, glucuronic acid, and proteins, named peptidorhamnomannan, which harbors important Sporothrix-specific immunogenic epitopes. Although the peptidorhamnomannan carbohydrate moiety has been …

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Comparison of Cell Wall Polysaccharide Composition and Structure Between Strains of Sporothrix schenckii and Sporothrix brasiliensis

Héctor Villalobos-Duno, Laura Barreto, Álvaro Alvarez-Aular, Hector Manuel Mora-Montes et autres

Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa are the main causative agents of sporotrichosis, a human subcutaneous mycosis. Differences in virulence patterns are associated with each species but remain largely uncharacterized. The S. schenckii and S. brasiliensis cell wall composition and virulence …

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Influences of the Culturing Media in the Virulence and Cell Wall of Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa

Nancy E. Lozoya‐Pérez, Diana M. Clavijo-Giraldo, Iván Martínez-Duncker, Laura Cristina García-Carnero et autres

Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa are etiological agents of sporotrichosis, a human subcutaneous mycosis. Although the protocols to evaluate Sporothrix virulence in animal models are well described, the cell preparation before inoculation is not standardized, and several culturing media are …

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Expression of Paracoccidioides brasiliensis AMY1 in a Histoplasma capsulatum amy1 Mutant, Relates an α-(1,4)-Amylase to Cell Wall α-(1,3)-Glucan Synthesis

Victoria E. Sepúlveda, William E. Goldman, Emma Camacho, Gustavo A. Niño‐Vega et autres

In the cell walls of the pathogenic yeast phases of Paracoccidioides brasiliensis, Blastomyces dermatitidis and Histoplasma capsulatum, the outer α-(1,3)-glucan layer behaves as a virulence factor. In H. capsulatum, an α-(1,4)-amylase gene (AMY1) is essential for the synthesis of this polysaccharide, hence …

Editorial: The Fungal Cell Wall

Fausto Bruno dos Reis Almeida, Joshua Daniel Nosanchuk, Gustavo A. Niño‐Vega

EDITORIAL article Front. Microbiol., 09 September 2020Sec. Fungi and Their Interactions Volume 11 - 2020 | https://doi.org/10.3389/fmicb.2020.01682

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