Nicholas H. F. Fine

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves et autres

The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of diabetes and obesity, yet visualizing the endogenous localization, organization and dynamics of …

gb, de (code pays fourni par la source)

Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo

Julia Ast, Alissa N. Novak, Tom Podewin, Nicholas H. F. Fine et autres

High Resolution Image Download MS PowerPoint Slide The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack …

gb, us, de (code pays fourni par la source)

The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

S. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal et autres

Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease. C2C12 myotubes were serum and amino acid starved …

gb (code pays fourni par la source)

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Julia Ast, Alissa N. Novak, Tom Podewin, Nicholas H. F. Fine et autres

The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack of validated reagents. Previously, we generated LUXendins, …

gb, us, de (code pays fourni par la source)

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Julia Ast, Alissa N. Novak, Tom Podewin, Nicholas H. F. Fine et autres

The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack of validated reagents. Previously, we generated LUXendins, …

gb, us, de (code pays fourni par la source)

Author Correction: PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Daniela Nasteska, Nicholas H. F. Fine, Fiona Ashford, Federica Cuozzo et autres

The original version of this Article contained an error in ref. 45, which was incorrectly given with the wrong author name as: Dzeja, P. et al. Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin …

gb, de, sg, it, us (code pays fourni par la source)

Author Correction: Optical control of L-type Ca2+ channels using a diltiazem photoswitch

Timm Fehrentz, Florian M. E. Huber, Nina Hartrampf, Tobias Bruegmann et autres

de, us, gb, at, ru, ca (code pays fourni par la source)

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Daniela Nasteska, Nicholas H. F. Fine, Fiona Ashford, Federica Cuozzo et autres

Abstract Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contribute to islet operation. Functional mapping …

gb, de, sg, it, us (code pays fourni par la source)

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

S. Neda Mousavy Gharavy, Bryn M. Owen, Steven J. Millership, Pauline Chabosseau et autres

Abstract Aims/hypothesis Variants close to the VPS13C / C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role …

gb, de, us, se, fr, ch, be, sg (code pays fourni par la source)

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska et autres

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

gb, ca, us, de (code pays fourni par la source)

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska et autres

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

gb, ca, us, de (code pays fourni par la source)

Mature and immature β-cells both contribute to islet function and insulin release

Daniela Nasteska, Nicholas H. F. Fine, Fiona Ashford, Federica Cuozzo et autres

Abstract Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that differences in β-cell maturity, defined using PDX1 and MAFA expression, are required for proper islet operation. Functional …

gb, de, it, us (code pays fourni par la source)