Mark Fedyk

Ten Questions for Ethics Committees Evaluating the Strength of Evidence in Support of Early Phase Trials

Spencer Phillips Hey, Mark Fedyk, Jonathan Kimmelman

Assessing the risks and benefits of early-phase clinical trials presents a persistent challenge for research ethics committees. These trials often lack direct, supporting evidence of clinical safety and efficacy, requiring ethics reviewers to evaluate a complex, heterogeneous body of preclinical and mechanistic …

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Justification of deferral of consent in the ACT-GLOBAL adaptive platform trial in stroke

Michel Christopher Frank Shamy, Nishita Singh, Aravind Ganesh, Carol C Kenney et autres

OBJECTIVE: Launched in August 2024, the ACT-GLOBAL (a multifactorial, multiarm, multistage, randomized, global adaptive platform) trial is the first multinational adaptive platform trial for acute stroke. Because it proposes to enroll participants by deferral of consent, the ACT-GLOBAL trial seeks to publish …

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Different Meanings of “Safety”

Theresa A. Harvath, Mark Fedyk

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When Safety Matters Most to a Provider but Not the Older Adult

Theresa A. Harvath, Mark Fedyk

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Long-Term Care Facilities and the Staff’s Perspective

Theresa A. Harvath, Mark Fedyk

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Independence Versus Autonomy

Theresa A. Harvath, Mark Fedyk

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How Prioritizing Safety Can Backfire

Theresa A. Harvath, Mark Fedyk

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Sex and the Nursing Home

Theresa A. Harvath, Mark Fedyk

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Our Suggestions for Dealing with Impossible Choices

Theresa A. Harvath, Mark Fedyk

This chapter concludes our exploration of ethical dilemmas in caring for older adults by offering a summary of practical suggestions. We emphasize that many choices in this field are “impossible choices,” where no single “right” answer exists. Instead of seeking certainty, we …

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What If Maslow Was Wrong?

Theresa A. Harvath, Mark Fedyk

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What If Maslow Was Wrong?

Theresa A. Harvath, Mark Fedyk

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Impossible Choices and Cost-Benefit Analysis

Theresa A. Harvath, Mark Fedyk

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