Jennifer D. McBride

Metastatic Small Cell Lung Cancer Masquerading as a Pancreatic Mass: A Case Report

Arjun R Gampala, Divya Minnaganti, M R Cooper, Jessi O'Neill-Smith et autres

Small cell lung cancer (SCLC) is notorious for its aggressive behavior and propensity for metastasis. Although metastasis to the pancreas from SCLC is relatively rare, it warrants attention due to its overlapping symptomatology with primary pancreatic malignancies and other abdominal pathologies (such …

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A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity

Deqiu Zhu, Baric R.S, Amila O. De Silva, T Scobey et autres

The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are implicated in enhanced viral replication and more severe disease. Current dengue tetravalent vaccines contain four live …

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Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization

Courtney A. Marshall, Jennifer D. McBride, Lakshmi N. Changolkar, Dawn M. Riddle et autres

Alzheimer's disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display increases in hyperphosphorylated tau and synaptic activity. Previous studies have individually identified the role of NR2B subunit-containing NMDA receptors in AD related …

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Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease

Maiko T. Uemura, John L. Robinson, Katheryn A Q Cousins, Thomas F. Tropea et autres

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Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Clayton Vasey, Jennifer D. McBride, Kayla L. Penta

Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the …

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In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

Hong Wei Xu, Mia O’Reilly, Garrett S. Gibbons, Lakshmi N. Changolkar et autres

The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and biochemically defined as distinct tau strains. Recent studies show that these tau strains exhibit strain-specific biological activities, also referred to as pathogenicities, in …

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Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo

Sarah A. Weitzman, Sneha Narasimhan, Zhuohao He, Lakshmi N. Changolkar et autres

One hallmark of neurodegenerative diseases is the intracellular accumulation of hyperphosphorylated tau protein, a neuronal microtubule-associated protein, into structures known as neurofibrillary tangles. Tauopathies are heterogeneous neurodegenerative diseases caused by the misfolding of the tau protein. It has been previously shown that …

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Transmission of tauopathy strains is independent of their isoform composition

Zhuohao He, Jennifer D. McBride, Hong Wei Xu, Lakshmi N. Changolkar et autres

The deposition of pathological tau is a common feature in several neurodegenerative tauopathies. Although equal ratios of tau isoforms with 3 (3R) and 4 (4R) microtubule-binding repeats are expressed in the adult human brain, the pathological tau from different tauopathies have distinct …

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Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

Bob Olsson, Erik Portelius, Nicholas C. Cullen, Åsa Sandelius et autres

Importance: Neuronal and axonal destruction are hallmarks of neurodegenerative diseases, but it is difficult to estimate the extent and progress of the damage in the disease process. Objective: To investigate cerebrospinal fluid (CSF) levels of neurofilament light (NFL) protein, a marker of …

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Elevated CSF GAP‐43 is Alzheimer's disease specific and associated with tau and amyloid pathology

Åsa Sandelius, Erik Portelius, Åsa Källén, Henrik Zetterberg et autres

INTRODUCTION: The level of the presynaptic protein growth-associated protein 43 (GAP-43) in cerebrospinal fluid (CSF) has previously been shown to be increased in Alzheimer's disease (AD) and thus may serve as an outcome measure in clinical trials and facilitate earlier disease detection. …

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Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology

Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C. Cullen et autres

Neurogranin (Ng) is a post-synaptic protein that previously has been shown to be a biomarker for synaptic function when measured in cerebrospinal fluid (CSF). The CSF concentration of Ng is increased in Alzheimer's disease dementia (ADD), and even in the pre-dementia stage. …

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Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

Zhuohao He, Jing Guo, Jennifer D. McBride, Sneha Narasimhan et autres

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