Fengxiang Yun

Intermittent fasting ameliorates resistant hypertension through modulation of gut microbiota

Fengxiang Yun, Xuejie Han, Zhiqi Wang, Mingcheng Xu et autres

Resistant hypertension (RH) remains a major cardiovascular challenge despite optimal pharmacological treatment. Intermittent fasting (IF) has demonstrated beneficial effects in various diseases, but its impact on RH and the underlying mechanisms remain unclear. In this study, we explored the effects of a …

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PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Rong Yan et autres

Increasing evidence has clarified that atrial fibrillation (AF) is associated with enhanced glycolysis, leading to lactate accumulation. However, whether glycolysis promotes AF remains unknown, as does whether histone lactylation plays a role in its pathogenesis. In the study, spontaneous AF mice are …

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Gut Microbiota-Derived Leucine Promotes Cold-Induced Atherosclerosis by Inhibiting Macrophage Efferocytosis

Yongtai Gong, Sen Rong Yan, Ning Fang, Yun Zhang et autres

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Sacubitril/valsartan attenuates atrial electrical and structural remodelling in a rabbit model of atrial fibrillation

Luyifei Li, Qi Lou, Guangzhong Liu, Jiachen Lv et autres

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Alterations in atrial ion channels and tissue structure promote atrial fibrillation in hypothyroid rats

Jianqiang Li, Zhaorui Liu, Hongwei Zhao, Fengxiang Yun et autres

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Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel

Yue Yuan, Jing Zhao, Yongtai Gong, Dingyu Wang et autres

Abstract Autophagy, a bidirectional degradative process extensively occurring in eukaryotes, has been revealed as a potential therapeutic target for several cardiovascular diseases. However, its role in atrial fibrillation (AF) remains largely unknown. This study aimed to determine the role of autophagy in …

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Thoracic Epidural Anesthesia Reversed Myocardial Fibrosis in Patients With Heart Failure Caused by Dilated Cardiomyopathy

Dan Ma, Lei Liu, Hongwei Zhao, Ruiying Zhang et autres

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An Effective Treatment for Heart Failure Caused by Valvular Heart Diseases: Thoracic Sympathetic Block

Dan Li, Wei Liu, Dan Ma, Fengxiang Yun et autres

BACKGROUND: The pilot study is designed to investigate the effect of continuous thoracic sympathetic block (TSB) on cardiac function, reconstruction, and hemodynamic parameters in patients with heart failure resulting from valvular heart disease. METHOD: The cardiac function parameters, including left ventricle ejection …

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Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model

Xue Ding, Chengyuan Yu, Yang Liu, Sen Rong Yan et autres

// Xue Ding 1,* , Chengyuan Yu 1,* , Yang Liu 1 , Sen Yan 1 , Wenpeng Li 1 , Dingyu Wang 1 , Li Sun 1 , Yu Han 1 , Minghui Li 1 , Song Zhang 1 , Fengxiang …

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Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway

Li Sun, Song Zhang, Chengyuan Yu, Zhenwei Pan et autres

Autophagy plays an important role in liver triglyceride (TG) metabolism. Inhibition of autophagy could reduce the clearance of TG in the liver. Hydrogen sulfide (H2S) is a potent stimulator of autophagic flux. Recent studies showed H2S is protective against hypertriglyceridemia (HTG) and …

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Atrial sympathetic remodeling in experimental hyperthyroidism and hypothyroidism rats

Lei Liu, Fengxiang Yun, Hongwei Zhao, Song Zhang et autres

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Valsartan Reduced Atrial Fibrillation Susceptibility by Inhibiting Atrial Parasympathetic Remodeling through MAPKs/Neurturin Pathway

Lei Liu, Jian-qiang Geng, Hongwei Zhao, Fengxiang Yun et autres

BACKGROUND/AIMS: Angiotensin II receptor blockers (ARBs) have been proved to be effective in preventing atrial structural and electrical remodelinq in atrial fibrillation (AF). Previous studies have shown that parasympathetic remodeling plays an important role in AF. However, the effects of ARBs on …

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