Emily J. Koubek

NONcNZO10 / LtJ and TALLY ‐ HO / JngJ Mice as Novel Models of Diabetic Peripheral Neuropathy

Stéphanie Eid, Andrew Carter, Emily J. Koubek, John M. Hayes et autres

Diabetic peripheral neuropathy (DPN), a severe complication of Type 2 diabetes (T2D), is marked by progressive distal-to-proximal axonal degeneration. Although animal models have advanced our understanding of DPN pathogenesis, preclinical successes rarely translate into effective therapies, underscoring the need for models that …

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Titre indisponible

E. Dale Abel, Peter Arvan, George L. Bakris, Ashok Balasubramanyam et autres

Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic Targets

Stéphanie Eid, Amy E. Rumora, Emily J. Koubek, Eva L. Feldman

Voluntary wheel running decreases intraepidermal nerve fibers in healthy mice

Stéphanie Eid, John M. Hayes, Andrew Carter, William Lentz et autres

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Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang et autres

We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty-one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI. Compared to normative data, participants showed …

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Abstract 3156: Pharmacokinetics of a series of anticancer agents in immunodeficient female NOD scid gamma mice

Mohd Beshr Chama, Emily J. Koubek, Sarah A. Buhrow, Renee A. Schoon et autres

Abstract Introduction: We aimed to characterize the preclinical pharmacokinetics (PK) of a series of 20 anticancer agents in highly immunodeficient female NOD scid gamma (NSG) mice to provide clearance and exposure data for agents under investigation by the NCI PDX Development and …

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Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

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Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

Animal Models for Neuropathic Pain Research in Type 1 and Type 2 Diabetes

Stéphanie Eid, Emily J. Koubek, Eva L. Feldman

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Identifying lifelong factors that impact brain health and functional outcomes in adults with childhood-onset type 1 diabetes: the cognition and longitudinal assessments of risk factors over 30 years (CLARiFY) – diabetes complications study protocol

Amy M. Brown, Stacey A. Sakowski, Chris G Moran, Emily J. Koubek et autres

INTRODUCTION: Type 1 diabetes (T1D) is associated with changes in brain structure, cognition, mental health, and functional outcomes. While these changes have been linked to dysregulated glycaemic control, findings are inconsistent, and their long-term impact remains unclear. Most evidence comes from cross-sectional …

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Abstract 4265: The role of the mevalonate pathway in post-translational modifications of PD-L1

Ruoheng Zhang, Emily J. Koubek, Jessie L. Reed, Jeffrey D. Neighbors et autres

Abstract Introduction: The binding of Programmed Death-Ligand 1 (PD-L1) on the surface of tumor cells to PD-1 on T cells prevents T-cell-mediated anti-cancer immune responses. Immune checkpoint blockades that target the PD-L1/PD-1 interaction have improved survival rates but have several critical limitations. …

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