Junqiang Dai

Pubertal maturation, genetic variation, and ventral striatal development in adolescence: An integrative framework

Anushka Mandar Phadke, Junqiang Dai

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Niraparib in pancreatic cancer with germline or somatic DNA damage repair (DDR) gene alterations (BRCA and beyond): a phase II study (NIRA-PANC)

MPH Anup Kasi MD, Raed Moh’d Taiseer Al-Rajabi, Joaquina Baranda, Anwaar Saeed et autres

BACKGROUND: Globally, pancreatic cancer is one of the leading causes of cancer-related mortality. Although FDA-approved chemotherapy regimens are available, rapid deterioration is often observed after first-line treatment. The PARP inhibitor niraparib may offer a therapeutic benefit in patients with advanced pancreatic cancer, …

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The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial

Catherine F. Siengsukon, Lauren Hand, Eryen Nelson, Allison Glaser et autres

INTRODUCTION: Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ) burden. METHODS: Cognitively normal older adults with symptoms of insomnia …

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A Systematic Review on Dysconnectivity in Face and Emotion Processing Networks in Schizophrenia

Amritha Harikumar, Junqiang Dai, Elaine F. Walker, Vince D. Calhoun

Introduction Schizophrenia is a complex psychiatric disorder which affects approximately 20 million people worldwide. Patients show face processing deficits which greatly affects their social interactions and social cognitive abilities (i.e. trouble empathizing with others). Face processing is an important skill that allows …

Neurodevelopment of Emotional Processes in Adolescent Social Contexts

Michelle Shipkova, Junqiang Dai, Kristen A. Lindquist, Eva H. Telzer

Adolescence is marked by both normative changes in neural systems associated with emotion and increased sensitivity to social influences, especially from peers. Whereas the influences of caregiver emotion socialization practices on the emotional development of youths are well-studied, less is understood about …

765P Interim analysis of protector-C study: A prospective, multicenter cohort of utilizing circulating tumor DNA (ctDNA) methylation as postoperative surveillance for colorectal cancer (CRC)

Xinyue Wang, Gang Chen, Zhoufeng Wang, Guixue Wang et autres

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Similarity of Biological Information Captured by [ 68 ]Ga-PSMA-11 PET and ASL Perfusion MRI in Glioblastoma

Yuping Han, Zhencun Cui, Wanjun Hu, Xiangrong Cao et autres

ABSTRACT BACKGROUND AND PURPOSE: To further elucidate the potential biological mechanisms underlying the uptake of PSMA-targeted radioligands in glioblastoma (GBM) and to clarify the value of prostate-specific membrane antigen (PSMA) PET in characterizing the spatial heterogeneity of GBM microvascular distribution, this study …

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Abstract P3-11-17: A Randomized Phase II Trial of Neo-adjuvant Chemotherapy with Metformin or Placebo for HER-2 Positive Operable Breast Cancer (The HERMET Trial)

Maire Okoniewski, Cory Bivona, Colleen Bohnenkamp, Francisco Martínez Díaz et autres

Abstract Background: Human epidermal growth factor receptor 2 (HER-2) is overexpressed in 15-20% of breast cancer (BC). Pathologic complete response (pCR) after HER-2 directed chemotherapy is an important surrogate marker for survival in HER-2+ operable BC. Patients with diabetes who receive metformin …

A Systematic Review on Dysconnectivity in Face and Emotion Processing Networks in Schizophrenia

Amritha Harikumar, Junqiang Dai, Elaine F. Walker, Vince D Calhoun

Introduction Schizophrenia is a complex psychiatric disorder which affects approximately 20 million people worldwide. Patients show face processing deficits which greatly affects their social interactions and social cognitive abilities (i.e. trouble empathizing with others). Face processing is an important skill that allows …

How Is Race Perceived During Adolescence? A Meta-Analysis of the Own-Race Bias

Junqiang Dai, Jason W. Griffin, K. Suzanne Scherf

Adolescence is a critical developmental period that is marked by drastic changes in face recognition, which are reflected in patterns of bias (i.e., superior recognition for some individuals compared to others). Here, we evaluate how race is perceived during face recognition and …

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Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest

Yusong Luo, Ruolan Liu, He Zhang, Hongyu Wang et autres

Glioma is a common primary nervous system malignant tumor with poor overall cure rate and low survival rate, yet successful treatment still remains a challenge. Here, we demonstrated that amantadine (AMT) exhibits the powerful anti-glioma effect by promoting apoptosis and autophagy in …

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563P Preliminary analysis in Protector-C study: A prospective, multicenter cohort of utilizing circulating tumor DNA (ctDNA) methylation as postoperative surveillance for colorectal cancer (CRC)

Zhen Liu, W. Zhang, Gang Chen, Guixue Wang et autres

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