Geoffrey Cotin

Data associated with the publication: Magnetically labelled iPSC-derived extracellular vesicles enable MRI/MPI-guided regenerative therapy for myocardial infarction

Wenshen Wang, Zheng Han, Safiya Aafreen, Cristina Zivko et autres

This repository contains data and analysis files for replicating the results presented in "Magnetically Labelled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction" (Journal of Extracellular Vesicles, 2025; 14:e70178). In this project, we developed magnetically labeled iPSC-derived extracellular vesicles (magneto-iPSC-EVs) …

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MPI quantification of magnetically labeled extracellular vesicles in mouse heart following myocardial infarction

Wenshen Wang, Zheng Han, Safiya Aafreen, Cristina Zivko et autres

This study aims to develop magnetically labeled iPSC-derived extracellular vesicles (magneto-EVs) for MRI/MPI and myocardial repair in a theranostic manner. Using optimized electroporation and purification protocols, we prepared magneto-EVs with high SuperSPIO20 loading efficiency (1.77 ng Fe/10? EVs) and well-preserved therapeutic effects. …

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Dendronized iron oxide: SUPERSPIO20 as MPI tracer and magnetic hyperthermia agent

Delphine Felder-Flesch, Laura Streit, Sara Jakimoska, Isis Blanchard et autres

The rise of MPI technology has led to the growing development of equipment requiring the use of an optimized magnetic tracer for increased sensitivity and resolution. In addition, MPI technology paves the way for truly targeted tumour treatment using the field free …

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Magnetically Labelled iPSC‐Derived Extracellular Vesicles Enable MRI/MPI‐Guided Regenerative Therapy for Myocardial Infarction

Wenshen Wang, Zheng Han, Safiya Aafreen, Cristina Zivko et autres

ABSTRACT Stem cell‐derived extracellular vesicles (EVs) offer a promising cell‐free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labelled induced pluripotent stem cell‐derived EVs (magneto‐iPSC‐EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image‐guided regenerative treatment of myocardial infarction, …

us (code pays fourni par la source)

Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction

Wenshen Wang, Zheng Han, Safiya Aafreen, Cristina Zivko et autres

Abstract Stem cell-derived extracellular vesicles (EVs) offer a promising cell-free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labeled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, …

us (code pays fourni par la source)

A Confinement‐Driven Nucleation Mechanism of Metal Oxide Nanoparticles Obtained via Thermal Decomposition in Organic Media

Geoffrey Cotin, Benoı̂t Heinrich, Francis Perton, Céline Kiefer et autres

Thermal decomposition is a very efficient synthesis strategy to obtain nanosized metal oxides with controlled structures and properties. For the iron oxide nanoparticle synthesis, it allows an easy tuning of the nanoparticle's size, shape, and composition, which is often explained by the …

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Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry

Alexandre Adam, Sébastien Harlepp, Fiorela Ghilini, Geoffrey Cotin et autres

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In situ liquid transmission electron microscopy reveals self-assembly-driven nucleation in radiolytic synthesis of iron oxide nanoparticles in organic media

Nathaly Ortiz Peña, Dris Ihiawakrim, Sorina Creţu, Geoffrey Cotin et autres

liquid phase transmission electron microscopy (IL-TEM). Before nucleation, we have evidenced the spontaneous formation of vesicular assemblies made of iron polycation-based precursors sandwiched between stearate layers. Nucleation of iron oxide nanoparticles occurs within the walls of the vesicles, which subsequently collapse upon …

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The Size, Shape, and Composition Design of Iron Oxide Nanoparticles to Combine, MRI, Magnetic Hyperthermia, and Photothermia

Barbara Freis, Geoffrey Cotin, Francis Perton, Damien Mertz et autres

In the field of the synthesis and functionalization of inorganic nanoparticles (NPs) for biomedical applications, most researches aim at developing multifunctional theranostic NPs, which can both identify disease states and deliver therapy and thus allow following the effect of therapy by imaging. …

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Iron Stearate Structures: An Original Tool for Nanoparticles Design

Francis Perton, Geoffrey Cotin, Céline Kiefer, Jean‐Marc Strub et autres

Iron carboxylates are widely used as iron precursors in the thermal decomposition process or considered as in situ formed intermediate precursors. Their molecular and three-dimensional (3D)-structural nature has been shown to affect the shape, size, and composition of the resulting iron oxide …

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Tuning size and shape of iron oxide nanoparticles ensuring multimodal therapy for head and neck cancers

Barbara Freis, Geoffrey Cotin, Francis Perton, C. Kiefer et autres

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Orienting the Pore Morphology of Core-Shell Magnetic Mesoporous Silica with the Sol-Gel Temperature. Influence on MRI and Magnetic Hyperthermia Properties

Alexandre Adam, Ksenia V. Parkhomenko, Paula Dueñas-Ramirez, Clémence Nadal et autres

The controlled design of robust, well reproducible, and functional nanomaterials made according to simple processes is of key importance to envision future applications. In the field of porous materials, tuning nanoparticle features such as specific area, pore size and morphology by adjusting …

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