Ekaterina A. Perina

Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver

Evgeny E. Buyko, Ekaterina A. Perina, Danil S. Sobakin, Matvey M. Tsyganov et autres

The use of postmortem (autopsy) material in fundamental and applied biomedical research significantly facilitates the collection of biomaterial for statistically robust sample cohorts. However, natural adaptive processes to developing cellular stress in the early postmortem period, caused by oxygen and nutrient deprivation, …

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Chronic opisthorchiasis invasion as a factor aggravating the development of cholangiocellular carcinoma. A literature review

Vladimir V. Ivanov, Т. Б. Комкова, Ekaterina A. Perina, L. V. Petrov et autres

Objective: to summarize current literature data indicating the feasibility of using invasive and non-invasive procedures for the early detection of cholangiocarcinoma, and to identify associations with chronic opisthorchiasis invasion. Material and Methods . A literature search was conducted using Web of Science, …

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Opisthorchiasis and pancreatic cancer

Vladimir V. Ivanov, Т. Б. Комкова, I. A. Lyzko, Ekaterina A. Perina et autres

Chronic opisthorchiasis is recognized as a precancerous condition that can present similarly to other diseases of the hepatopancreatoduodenal zone. Statistically, there is a proven correlation between the duration and intensity of parasitic invasion and the development of carcinogenesis, with the manifestations of …

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A new approach to assessing the efficacy of anthelmintic agents in vitro

Ekaterina A. Perina, E. E. Buyko, I. P. Kaminskiy, Danil S. Sobakin et autres

Aim. To develop a new method to determine the viability of Opisthorchis felineus in vitro using the MTS reagent and to evaluate its applicability for analyzing the efficacy of anthelmintic agents in the treatment of opisthorchiasis. Materials and methods. Golden hamsters were …

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Dynamic changes in RNA integrity, gene expression, and tissue pathomorphology of experimental mice in the postmortem period

E. E. Buyko, Ekaterina A. Perina, Dmitry V. Vasilchenko, Irina Aleksandrovna Tsydenova et autres

Aim. To examine the pattern of morphological changes, RNA quality number, and gene expression in mouse tissues sampled at autopsy under controlled experimental conditions. Materials and methods. Balb/c mice were euthanized and subsequently subjected to necropsy at 0, 3, 12, 24, 48, …

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Precision medicine in oncology: role and prospects of mass spectrometry

E. S. Khmelevskaya, Ekaterina A. Perina, E. E. Buyko, Alexander A. Ufandeev et autres

The aim of this review was to analyze the accumulated data on the use of mass spectrometry in diagnosing, treating, and prognosing cancer from the perspective of precision medicine. Currently, universally accepted methods for early cancer diagnosis are not available, primarily due …

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Prevention of Metastasis by Suppression of Stemness Genes Using a Combination of microRNAs

K. V. Nevskaya, Alexandra G. Pershina, Ekaterina S. Hmelevskaya, Lina V. Efimova et autres

We propose an original strategy for metastasis prevention using a combination of three microRNAs that blocks the dedifferentiation of cancer cells in a metastatic niche owing to the downregulation of stemness genes. Transcriptome microarray analysis was applied to identify the effects of …

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Foresight in the diagnosis of trematodiasis: innovations versus routine methods

Ekaterina A. Perina, E. S. Khmelevskaya, Olga Sergeevna Fedorova, Vladimir V. Ivanov

Aim. To analyze modern methods for the diagnosis of trematodiasis in experimental and epidemiological studies. Trematodiasis is a group of common parasitic diseases that are a socially sensitive health problem worldwide. According to World Health Organization, more than 250 million people are …

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Metabolic Homeostasis in Chronic Helminth Infection Is Sustained by Organ-Specific Metabolic Rewiring

Daria A. Kokova, Aswin Verhoeven, Ekaterina A. Perina, Vladimir V. Ivanov et autres

High Resolution Image Download MS PowerPoint Slide Opisthorchiasis, is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae . A chronic form of the disease implies a prolonged coexistence of a host and the parasite. The pathological changes inflicted by …

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Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus)

Daria A. Kokova, Aswin Verhoeven, Ekaterina A. Perina, Vladimir V. Ivanov et autres

BACKGROUND: Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae. Opisthorchiasis can lead to severe hepatobiliary morbidity and is classified as a carcinogenic agent. Here we investigate the time-resolved metabolic response to Opisthorchis felineus infection in an animal …

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Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis

Ekaterina A. Perina, Vladimir V. Ivanov, Alexandra G. Pershina, Natalya A. Perekucha et autres

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Metabolic syndromes, carbohydrate and lipid metabolism disorders in helminthic infections: review of the literature

Ekaterina A. Golovach, Olga Sergeevna Fedorova, Т. В. Саприна, V. V. Ivanov et autres

Metabolic syndrome is a common pathological condition based on an increase of the mass of visceral fat, insulin resistance with hyperinsulinemia, carbohydrate, lipid and protein disorders. The natural course of the metabolic syndrome can be affected by the presence of intercurrent diseases …

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