Adam L. Cohen

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Group A Streptococcal Pharyngitis: Risk Assessment Using Clinical Scoring Systems in Children and Adults

Jeffrey A. Linder, Michael E. Watson, Michael R. Wessels, Danielle M Carter et autres

This publication represents the first part of an update to the clinical practice guideline on the diagnosis and management of group A streptococcal (Streptococcus pyogenes or GAS) pharyngitis, developed by the Infectious Diseases Society of America (IDSA). Diagnosis of GAS pharyngitis by …

us (code pays fourni par la source)

New Pneumococcal Vaccine Recommendation for U.S. Adults Aged 50 Years and Older—Promise and Challenges

Miwako Kobayashi, Jamie Loehr, Virginia Caine, Adam L. Cohen

us (code pays fourni par la source)

Pneumococcal Serotype Distribution and Coverage of Existing and Pipeline Pneumococcal Vaccines

Laura King, Kristin L. Andrejko, Miwako Kobayashi, Wei Xing et autres

BACKGROUND: Next-generation pneumococcal conjugate vaccines (PCVs) target an expanding array of serotype antigens. We assessed the proportions of invasive pneumococcal disease (IPD) and pneumococcal acute respiratory infections (ARIs) caused by serotypes targeted by existing and pipeline PCVs, and the annual United States …

us (code pays fourni par la source)

Abstract P2-12-24: A phase I/Ib trial of the CDK4/6 antagonist ribociclib and the HDAC inhibitor belinostat in patients with metastatic triple negative breast cancer and recurrent ovarian cancer with response prediction by genomics (CHARGE)

Talicia Savage, John G. Lamb, Elyse D’Astous, Shashank Sama et autres

Abstract Rationale: Metastatic triple negative breast cancer (TNBC) and recurrent ovarian cancer have poor prognoses with survival rates of approximately twenty-three months and thirty-two months, respectively. New treatment paradigms for these malignancies are needed. In Vivo studies have demonstrated promising results in …

The epidemiology of bacterial meningitis in the United States during 2008–2023: an analysis of active, laboratory, population-based, multistate surveillance data

Namrata Prasad, Miwako Kobayashi, Jennifer P. Collins, Amy B Rubis et autres

Background Bacterial meningitis is a severe syndrome with dynamic epidemiology, but assessments of current trends are limited. We aimed to describe changing epidemiologic patterns among common bacterial causes of meningitis in the United States. Methods We analyzed data on bacterial meningitis cases …

us (code pays fourni par la source)

Acute respiratory infections due to antibiotic-nonsusceptible Streptococcus pneumoniae in United States adults

Laura King, Kristin L. Andrejko, Miwako Kobayashi, Wei Xing et autres

Background: (pneumococcus) in US adults (≥18 years). Methods: We estimated antibiotic-nonsusceptible pneumococcal sinusitis and non-bacteremic pneumonia incidence as products of non-bacteremic pneumococcal pneumonia and sinusitis incidence rates, serotype distribution, and serotype-specific antimicrobial nonsusceptibility prevalences by antibiotic class and guideline-recommended agents from 2016-2019. …

us (code pays fourni par la source)

Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccines (the PSERENADE project): a global surveillance analysis

Maria Garcia Quesada, Meagan E. Peterson, Julia C. Bennett, Kyla Hayford et autres

BACKGROUND: Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive pneumococcal disease (IPD). We describe the serotype distribution of IPD after extensive use of ten-valent PCV (PCV10; Synflorix, GSK) and 13-valent PCV (PCV13; Prevenar 13, Pfizer) globally. METHODS: IPD data …

us, ch, Afrique du Sud, de, nl, es, no, Ouganda, Kenya, fr, dk, gr, si, bg, gb, lv, au, jp, fi, ar, Congo, se, ca, sk, Gambie, py, is, cz, cn, hk, nz, Malawi, Maroc, be, il, ie, cr, sg, br, cl (code pays fourni par la source)

PNEUMOCOCCAL SEROTYPE DISTRIBUTION AND COVERAGE OF EXISTING AND PIPELINE PNEUMOCOCCAL VACCINES

Laura King, Kristin L. Andrejko, Miwako Kobayashi, Wei Xing et autres

Background: (pneumococcus) causes invasive pneumococcal disease (IPD) and non-invasive acute respiratory infections (ARIs). Three pneumococcal conjugate vaccines (PCVs) are recommended in the United States with additional products in clinical trials. We aimed to estimate 1) proportions of IPD cases and pneumococcal ARIs …

us (code pays fourni par la source)

Two Outbreaks of Legionnaires Disease Associated with Outdoor Hot Tubs for Private Use — Two Cruise Ships, November 2022–July 2024

Sooji Lee, Chris Edens, Troy Ritter, Luis O. Rodriguez et autres

Legionnaires disease is a serious pneumonia caused by Legionella bacteria. During November 2022-June 2024, CDC was notified of 12 cases of Legionnaires disease among travelers on two cruise ships; eight on cruise ship A and four on cruise ship B. CDC, in …

us (code pays fourni par la source)

Risk factors for severe respiratory syncytial virus-associated respiratory tract infection in a high HIV prevalence setting, South Africa, 2012 – 2018

Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Adam L. Cohen et autres

BACKGROUND: Identifying risk factors for respiratory syncytial virus (RSV)-associated severe acute respiratory illness (SARI) will assist with targeting vaccine interventions. METHODS: Using surveillance data from South Africa (2012-2018), we compared the characteristics of individuals with RSV-associated influenza-like illness (ILI) (reference group) to …

Afrique du Sud, us, ch (code pays fourni par la source)

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices — United States, 2024

Miwako Kobayashi, Andrew J. Leidner, Ryan Gierke, Jennifer L. Farrar et autres

On June 17, 2024, the Food and Drug Administration approved 21-valent pneumococcal conjugate vaccine (PCV) (PCV21; CAPVAXIVE; Merck Sharp & Dohme, LLC) for adults aged ≥18 years.PCV21 does not contain certain serotypes that are included in other licensed pneumococcal vaccines but adds …

Risk factors for severe respiratory syncytial virus-associated respiratory tract infection in a high HIV prevalence setting, prior to the SARS-CoV-2 pandemic, South Africa, 2012 – 2018

Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Adam L. Cohen et autres

Abstract Background Identifying risk factors for respiratory syncytial virus (RSV)–associated severe acute respiratory illness (SARI) will assist with targeting vaccine interventions. Methods Using surveillance data from South Africa (2012-2018). We compared the characteristics of individuals with RSV-associated ILI (reference group) to those …

Afrique du Sud, us (code pays fourni par la source)