Clare Jacobs

Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial

Simon Parkinson Bach, David Sebag-Montefiore, Victoria Homer, Alexandra Gilbert et autres

BACKGROUND: Total mesorectal excision (TME) is the standard treatment for most early-stage and intermediate-stage rectal cancer but can cause substantial perioperative morbidity, functional impairment, and reduced quality of life. We assessed whether long-course chemoradiotherapy (LCCRT) or short-course radiotherapy (SCRT) could increase organ …

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Systemic complement protein levels as biomarkers of chemoradiotherapy response in anal squamous cell carcinoma

D. Majorová, Robert Samuel, R. Muirhead, Alexander Hasson et autres

BACKGROUND: Identification of easily measurable biomarkers that are able to predict locoregional failure or disease progression following chemoradiotherapy (CRT) would enable more personalised cancer management. Anal squamous cell cancer (ASCC) is the most common type of anal cancer, accounting for approximately 90% …

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2008 The management of anal squamous cell carcinoma in frail and elderly patients – is 30Gy enough?

Christakis Agathokleous, Clare Jacobs, Alexandra Gilbert, Rebecca Muirhead

Systemic complement protein levels as biomarkers of chemoradiotherapy response in anal squamous cell carcinoma

Dominika Majorova, Robert Samuel, Rebecca Muirhead, David MacLean et autres

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Implementing a pathway for patients diagnosed with cancer in the emergency department

Kay Joanne McCallum, Clare Jacobs

Patients diagnosed with cancer or suspected cancer during an emergency department (ED) presentation are often signposted back to their GP for urgent referral to cancer services. However, this can result in delays in patients receiving specialist support, confirmation of diagnosis and, vitally, …

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Development of an ambulatory assessment unit – acute oncology service MDT to provide safe follow up of new oncology patients presenting to an SDEC unit

Saman Jalilzadeh Afshari, Saniya Naseer, Joseph Gaied, Oliver Madge et autres

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Differential Response of Pelvic Bone Marrow Fluorodeoxyglucose Uptake in Patients Receiving Concurrent Chemoradiotherapy

Maxwell Robinson, Rebecca Muirhead, Daniel R. McGowan, Kwun-Ye Chu et autres

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PO-1276 Differential Response of FDG Uptake in Pelvic Bone Marrow to Concurrent Chemoradiotherapy

Maxwell Robinson, Rebecca Muirhead, Kwun-Ye Chu, Clare Jacobs et autres

A Prospective Study of Diffusion-weighted Magnetic Resonance Imaging as an Early Prognostic Biomarker in Chemoradiotherapy in Squamous Cell Carcinomas of the Anus

Rebecca Muirhead, Daniel Peter Bulte, Rosie Cooke, Kwun-Ye Chu et autres

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DPD testing in radical chemoradiation for anal squamous cell carcinoma

Helen J S Jones, Duncan Charles Gilbert, Alexandra Gilbert, Clare Jacobs et autres

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Oxygen-enhanced MRI MOLLI T1 mapping during chemoradiotherapy in anal squamous cell carcinoma

Emma Bluemke, Daniel Peter Bulte, Ambre Bertrand, Ben George et autres

Background and purpose Oxygen-enhanced magnetic resonance imaging (MRI) and T1-mapping was used to explore its effectiveness as a prognostic imaging biomarker for chemoradiotherapy outcome in anal squamous cell carcinoma. Materials and methods T2-weighted, T1 mapping, and oxygen-enhanced T1 maps were acquired before …

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Rectal Squamous Cell Carcinomas – Are They Really Rectal?

Hannah L. Williams, Stephen Boyce, Jun Uk Lim, Mayur S. Patel et autres

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