Mingjiang Yao

Catalpol Confers Neuroprotection against Cerebral Ischemic Injury by Regulating the Phosphatidylinositol 3-kinase/Protein Kinase B/Glycogen Synthase Kinase 3 Beta/β-catenin Signaling Pathway

Xiaoyu Zheng, G Wang, Heng Zhang, Xian Zhou et autres

Abstract Background: Ischemic stroke is a leading cause of long-term neurological disability worldwide. Within minutes of its onset, blood flow to the brain’s ischemic core drops dramatically, resulting in irreversible damage and eventual neuronal death in the affected area. Currently, effective clinical …

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Anatomical localization and acupuncture pathway of the sphenopalatine ganglion in Sprague–Dawley rats: a microanatomical study

Yuechun Zhao, Lei Li, Mingjiang Yao, Xiaojing An et autres

Background: The sphenopalatine ganglion (SPG) plays a pivotal role in regulating various head and facial diseases, such as cluster headaches, allergic rhinitis, and cerebral ischemia, through its neuroregulatory functions. Current interventions targeting SPG, have certain limitations, such as invasiveness and high cost. …

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Preclinical Studies of Chinese Herbal Medicine for Cognitive Impairments

Wenting Song, Ding Zhao, Xian Zhou, Dennis H-T Chang et autres

Cognitive impairment (CI) is the dysfunction of the brain&s;s advanced intelligence in learning, thinking, memory, language, and emotion and is accompanied by aphasia, loss of recognition, or disturbance in executive functioning. CI has become a significant public health issue affecting patients’ ability …

Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation

Jiarui Zheng, Weiming Wang, Wenting Song, Yehao Zhang et autres

Objective: experimental validation. Methods: Potential drug targets of FS and AV-related disease targets were systematically retrieved from TCMSP, SWISS Target Prediction, GeneCards, and DisGeNET databases. The putative therapeutic targets of FS against AV were identified through target overlap analysis between drug and …

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Baicalin Ameliorates L‐Glutamate‐Induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO‐1 Signalling Pathway

Feng Li, Zishan Huang, Jiarui Zheng, Mingjiang Yao

OBJECTIVE: This study aimed to explore the effect and mechanism of baicalin on L-glutamate-induced oxidative stress injury in the hippocampus of mice. METHODS: Forty mice were divided into five groups:Sham, model, N-acetyl-L-cysteine (NAC) and baicalin (BA-7.5 mg/kg and BA-15 mg/kg). A model …

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Qilong capsule regulates microglial function and inhibits platelet activation after multiple cerebral infarctions by regulating the P2Y12/AC/cAMP signalling pathway

Min Zhan, Jiaming Gao, Shengnan Shi, Wenting Song et autres

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Baicalin Ameliorates L-Glutamate-induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO-1 Signaling Pathway

Feng Li, Zishan Huang, Jiarui Zheng, Mingjiang Yao

Objective: To explore the effect and mechanism of baicalin on L-Glutamate-induced oxidative stress injury in the hippocampus of mice. Methods: Forty mice were randomly assigned to five groups: Sham, Model, N-Acetyl-L-Cysteine (NAC), and baicalin (BA-7.5mg/kg and BA-15mg/kg). A model of excitatory amino …

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Lingshao-Zaoren Decoction Attenuates Cyclophosphamide-Induced Overactive Bladder Via Piezo1/Ca² + and Apoptosis Pathway Modulation: Evidence from Pharmacodynamic and Uplc-Hrms Analysis

Tan Zailong, Mengdi Ding, Mingjiang Yao, Ran Luo et autres

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Catalpol promotes hippocampal neurogenesis and synaptogenesis in rats after multiple cerebral infarctions by mitochondrial regulation: involvement of the Shh signaling pathway

Zishan Huang, Feng Li, Xiaoyu Zheng, Jiarui Zheng et autres

Introduction: , which has the beneficial efficacy in traditional remedy, is closely related to the mitochondrial morphology and function. In the present study, we investigated whether catalpol has a neurorestorative effect after multiple cerebral infarctions and its underlying mechanisms. Methods: In this …

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Exploring the pharmacological mechanism of Tongluo Qingnao formula in treating acute ischemic stroke: A combined approach of network pharmacology, molecular docking and experimental evidences

Feng Li, Yilei Dong, Guangrui Wang, Zishan Huang et autres

Introduction Tongluo Qingnao (TLQN) Formula is a patent Traditional Chinese Medicine injection designed for the treatment of Acute Ischemic Stroke (AIS) and associated complications. Previous researches had shown promising potential of TLQN in treating ischemic brain edema. This study aimed to reveal …

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Salidroside ameliorates cerebral ischemic injury and regulates the glutamate metabolism pathway in astrocytes

Xiaoyu Zheng, Hongwei Zhang, Yehao Zhang, Ding Zhao et autres

Background and Aim: L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia. However, its efficacy and mechanism in cerebral ischemia remain unclear, particularly regarding its effect on glutamate (Glu) metabolism. In this paper, we aimed to investigate the efficacy …

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Traditional Chinese Medicine JianPiHuaTan formula improving quality of life and survival in patients with colorectal cancer through RAS/RAF downstream signaling pathways

Jian He, Guojun Li, Yu Wu, Tong Zhang et autres

Objective: JianPiHuaTan Formula (JPHTF), a traditional Chinese medicine (TCM), has been utilized as an adjunctive therapy for colorectal cancer (CRC). The study aims to evaluate the potential clinical benefits of JPHTF and its effectiveness in inhibiting tumor growth. Methods: 300 stage II/III …

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