Casimiro Luca Gigliotti

Erratum to “Gemcitabine-loaded ICOS-Fc decorated nanosponges: a new chemo immunotherapy combination against pancreatic cancer”. [Int. J. Pharm. 682 (2025) 125869]

Monica Argenziano, Chiara Monge, Anna Scomparin, Francesco Trotta et autres

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OPN‐Derived Peptides Generated by Proteasomes Can Promote Cell Migration via CD44 Activation

Hindh Imad, Kathryn E. Strange, Chiara Dianzani, Wai Tuck Soh et autres

Osteopontin (OPN) is a pleiotropic cytokine that is overexpressed in many autoimmune diseases and solid cancers. Here we show that the 20S proteasome can degrade, in vitro, both the full-length OPN and the OPN-C fragment generated in the extracellular space and produce …

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The Association of Axonal Damage Biomarkers and Osteopontin at Diagnosis Could Be Useful in Newly Diagnosed MS Patients

Eleonora Virgilio, Chiara Puricelli, Nausicaa Clemente, Valentina Ciampana et autres

(1) Background: Multiple sclerosis (MS) is a biologically highly heterogeneous disease and has poor predictability at diagnosis. Moreover, robust data indicate that early disease activity strongly correlates with future disability. Therefore, there is a need for strong and reliable biomarkers from diagnosis …

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Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma

Federica Blua, Chiara Monge, Simone Gastaldi, Nausicaa Clemente et autres

Cancer spreading through metastatic processes is one of the major causes of tumour-related mortality. Metastasis is a complex phenomenon which involves multiple pathways ranging from cell metabolic alterations to changes in the biophysical phenotype of cells and tissues. In the search for …

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Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis

Alessia Provera, Naresh Naik Ramavath, Laila Lavanya Gadipudi, Casimiro Luca Gigliotti et autres

Background and aims Inducible T-cell Co-Stimulator (ICOS) present on T-lymphocytes and its ligand ICOSL expressed by myeloid cells play multiple roles in regulating T-cell functions. However, recent evidence indicates that reverse signalling involving ICOSL is also important in directing the differentiation of …

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Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Chiara Puricelli, Casimiro Luca Gigliotti, Ian Stoppa, Sara Sacchetti et autres

Chronic inflammation contributes to the pathogenesis of many diseases, including apparently unrelated conditions such as metabolic disorders, cardiovascular diseases, neurodegenerative diseases, osteoporosis, and tumors, but the use of conventional anti-inflammatory drugs to treat these diseases is generally not very effective given their …

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Genes and Microbiota Interaction in Monogenic Autoimmune Disorders

Federica Costa, Eleonora Beltrami, Simona Mellone, Sara Sacchetti et autres

Monogenic autoimmune disorders represent an important tool to understand the mechanisms behind central and peripheral immune tolerance. Multiple factors, both genetic and environmental, are known to be involved in the alteration of the immune activation/immune tolerance homeostasis typical of these disorders, making …

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Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications

Elena Boggio, Casimiro Luca Gigliotti, Ian Stoppa, Deepika Pantham et autres

The most important limitations of chemotherapeutic agents are severe side effects and the development of multi-drug resistance. Recently, the clinical successes achieved with immunotherapy have revolutionized the treatment of several advanced-stage malignancies, but most patients do not respond and many of them …

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A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

Elisa Batoni, Amedeo Franco Bonatti, Carmelo De Maria, Kenny Dalgarno et autres

This work presents a computational model to study the degradation behavior of polyester-based three-dimensional (3D) functionalized scaffolds for bone regeneration. As a case study, we investigated the behavior of a 3D-printed scaffold presenting a functionalized surface with ICOS-Fc, a bioactive protein able …

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Platelets, Protean Cells with All-Around Functions and Multifaceted Pharmacological Applications

Chiara Puricelli, Elena Boggio, Casimiro Luca Gigliotti, Ian Stoppa et autres

Platelets, traditionally known for their roles in hemostasis and coagulation, are the most prevalent blood component after erythrocytes (150,000-400,000 platelets/μL in healthy humans). However, only 10,000 platelets/μL are needed for vessel wall repair and wound healing. Increased knowledge of the platelet's role …

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Differential Modulation of Human M1 and M2 Macrophage Activity by ICOS-Mediated ICOSL Triggering

Casimiro Luca Gigliotti, Chiara Dianzani, Ian Stoppa, Chiara Monge et autres

Activated T cells express the inducible T-cell co-stimulator (ICOS) that, upon binding to its ubiquitously expressed ligand (ICOSL), regulates the immune response and tissue repair. We sought to determine the effect of ICOS:ICOSL interaction on human M1 and M2 macrophages. M1 and …

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Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures

Federica Banche‐Niclot, Ilaria Corvaglia, Caterina Cavalera, Elena Boggio et autres

Vertebral compression fractures are typical of osteoporosis and their treatment can require the injection of a cement through a minimally invasive procedure to restore vertebral body height. This study reports the development of an injectable calcium sulphate-based composite cement able to stimulate …

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